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1.
Proc Natl Acad Sci U S A ; 121(45): e2412817121, 2024 Nov 05.
Artigo em Inglês | MEDLINE | ID: mdl-39432767

RESUMO

Biogenic isoprene emissions from herbaceous plants are generally lower than those from trees. However, our study finds widespread isoprene emission in herbaceous sedge plants, with a stronger temperature response surpassing current tree-derived models. We measured and compared isoprene emissions from sedges grown in different climatic zones, all showing an exponential temperature response with a Q10 range of 7.2 to 12, significantly higher than the Q10 of about 3 for other common isoprene emitters. The distinct temperature sensitivity of sedges makes them a hidden isoprene source, significant during heat waves but not easily detected in mild weather. For instance, isoprene emissions from Carex praegracilis can increase by 320% with a peak emission of over 100 nmol m-2 s-1 compared to preheat wave emissions. During heat waves, the peak isoprene emissions from C. praegracilis can match those from Lophostemon confertus, a commonly used street tree species which is considered the dominant urban isoprene source due to higher biomass and emission capacities. This surge in isoprene from globally distributed sedges, including those in urban landscapes, could contribute to peak ozone and aerosol pollutants during heat waves.

2.
Proc Natl Acad Sci U S A ; 121(12): e2318716121, 2024 Mar 19.
Artigo em Inglês | MEDLINE | ID: mdl-38483991

RESUMO

Deep convection in the Asian summer monsoon is a significant transport process for lifting pollutants from the planetary boundary layer to the tropopause level. This process enables efficient injection into the stratosphere of reactive species such as chlorinated very-short-lived substances (Cl-VSLSs) that deplete ozone. Past studies of convective transport associated with the Asian summer monsoon have focused mostly on the south Asian summer monsoon. Airborne observations reported in this work identify the East Asian summer monsoon convection as an effective transport pathway that carried record-breaking levels of ozone-depleting Cl-VSLSs (mean organic chlorine from these VSLSs ~500 ppt) to the base of the stratosphere. These unique observations show total organic chlorine from VSLSs in the lower stratosphere over the Asian monsoon tropopause to be more than twice that previously reported over the tropical tropopause. Considering the recently observed increase in Cl-VSLS emissions and the ongoing strengthening of the East Asian summer monsoon under global warming, our results highlight that a reevaluation of the contribution of Cl-VSLS injection via the Asian monsoon to the total stratospheric chlorine budget is warranted.

3.
Proc Natl Acad Sci U S A ; 121(39): e2401975121, 2024 Sep 24.
Artigo em Inglês | MEDLINE | ID: mdl-39284062

RESUMO

While the dominant role of halogens in Arctic ozone loss during spring has been widely studied in the last decades, the impact of sea-ice halogens on surface ozone abundance over the northern hemisphere (NH) mid-latitudes remains unquantified. Here, we use a state-of-the-art global chemistry-climate model including polar halogens (Cl, Br, and I), which reproduces Arctic ozone seasonality, to show that Arctic sea-ice halogens reduce surface ozone in the NH mid-latitudes (47°N to 60°N) by ~11% during spring. This background ozone reduction follows the southward export of ozone-poor and halogen-rich air masses from the Arctic through polar front intrusions toward lower latitudes, reducing the springtime tropospheric ozone column within the NH mid-latitudes by ~4%. Our results also show that the present-day influence of Arctic halogens on surface ozone destruction is comparatively smaller than in preindustrial times driven by changes in the chemical interplay between anthropogenic pollution and natural halogens. We conclude that the impact of Arctic sea-ice halogens on NH mid-latitude ozone abundance should be incorporated into global models to improve the representation of ozone seasonality.

4.
Proc Natl Acad Sci U S A ; 121(28): e2321770121, 2024 Jul 09.
Artigo em Inglês | MEDLINE | ID: mdl-38950370

RESUMO

Solar particle events (SPEs) are short-lived bursts of high-energy particles from the solar atmosphere and are widely recognized as posing significant economic risks to modern society. Most SPEs are relatively weak and have minor impacts on the Earth's environment, but historic records contain much stronger SPEs which have the potential to alter atmospheric chemistry, impacting climate and biological life. The impacts of such strong SPEs would be far more severe when the Earth's protective geomagnetic field is weak, such as during past geomagnetic excursions or reversals. Here, we model the impacts of an extreme SPE under different geomagnetic field strengths, focusing on changes in atmospheric chemistry and surface radiation using the atmosphere-ocean-chemistry-climate model SOCOL3-MPIOM and the radiation transfer model LibRadtran. Under current geomagnetic conditions, an extreme SPE would increase NOx concentrations in the polar stratosphere and mesosphere, causing reductions in extratropical stratospheric ozone lasting for about a year. In contrast, with no geomagnetic field, there would be a substantial increase in NOx throughout the entire atmosphere, resulting in severe stratospheric ozone depletion for several years. The resulting ground-level ultraviolet (UV) radiation would remain elevated for up to 6 y, leading to increases in UV index up to 20 to 25% and solar-induced DNA damage rates by 40 to 50%. The potential evolutionary impacts of past extreme SPEs remain an important question, while the risks they pose to human health in modern conditions continue to be underestimated.

5.
Proc Natl Acad Sci U S A ; 120(51): e2309312120, 2023 Dec 19.
Artigo em Inglês | MEDLINE | ID: mdl-38091286

RESUMO

Nonlinearity in photochemical systems is known to allow self-sustained oscillations, but they have received little attention in studies of planetary atmospheres. Here, we present a unique, self-oscillatory solution for ozone chemistry of an exoplanet from a numerical simulation using a fully coupled, three-dimensional (3D) atmospheric chemistry-radiation-dynamics model. Forced with nonvarying stellar insolation and emission flux of nitric oxide (NO), atmospheric ozone abundance oscillates by a factor of thirty over a multidecadal timescale. As such self-oscillations can only occur with biological nitrogen fixation contributing to NO emission, we propose that they are a unique class of biosignature. The resulting temporal variability in the atmospheric spectrum is potentially observable. Our results underscore the importance of revisiting the spectra of exoplanets over multidecadal timescales to characterizing the atmospheric chemistry of exoplanets and searching for exoplanet biosignatures. There are also profound implications for comparative planetology and the evolution of the atmospheres of terrestrial planets in the solar system and beyond. Fully coupled, 3D atmospheric chemistry-radiation-dynamics models can reveal new phenomena that may not exist in one-dimensional models, and hence, they are powerful tools for future planetary atmospheric research.

6.
Proc Natl Acad Sci U S A ; 120(11): e2213910120, 2023 Mar 14.
Artigo em Inglês | MEDLINE | ID: mdl-36877843

RESUMO

The 2019 to 2020 Australian summer wildfires injected an amount of organic gases and particles into the stratosphere unprecedented in the satellite record since 2002, causing large unexpected changes in HCl and ClONO2. These fires provided a novel opportunity to evaluate heterogeneous reactions on organic aerosols in the context of stratospheric chlorine and ozone depletion chemistry. It has long been known that heterogeneous chlorine (Cl) activation occurs on the polar stratospheric clouds (PSCs; liquid and solid particles containing water, sulfuric acid, and in some cases nitric acid) that are found in the stratosphere, but these are only effective for ozone depletion chemistry at temperatures below about 195 K (i.e., largely in the polar regions during winter). Here, we develop an approach to quantitatively assess atmospheric evidence for these reactions using satellite data for both the polar (65 to 90°S) and the midlatitude (40 to 55°S) regions. We show that heterogeneous reactions apparently even happened at temperatures at 220 K during austral autumn on the organic aerosols present in 2020 in both regions, in contrast to earlier years. Further, increased variability in HCl was also found after the wildfires, suggesting diverse chemical properties among the 2020 aerosols. We also confirm the expectation based upon laboratory studies that heterogeneous Cl activation has a strong dependence upon water vapor partial pressure and hence atmospheric altitude, becoming much faster close to the tropopause. Our analysis improves the understanding of heterogeneous reactions that are important for stratospheric ozone chemistry under both background and wildfire conditions.

7.
Proc Natl Acad Sci U S A ; 120(46): e2301994120, 2023 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-37903247

RESUMO

The explosive eruption of the Hunga Tonga-Hunga Ha'apai (HTHH) volcano on 15 January 2022 injected more water vapor into the stratosphere and to higher altitudes than ever observed in the satellite era. Here, the evolution of the stratospherically injected water vapor is examined as a function of latitude, altitude, and time in the year following the eruption (February to December 2022), and perturbations to stratospheric chemical composition resulting from the increased sulfate aerosols and water vapor are identified and analyzed. The average calculated mass distribution of elevated water vapor between hemispheres is approximately 78% Southern Hemisphere (SH) and 22% Northern Hemisphere in 2022. Significant changes in stratospheric composition following the HTHH eruption are identified using observations from the Aura Microwave Limb Sounder satellite instrument. The dominant features in the monthly mean vertical profiles averaged over 15° latitude ranges are decreases in O3 (-14%) and HCl (-22%) at SH midlatitudes and increases in ClO (>100%) and HNO3 (43%) in the tropics, with peak pressure-level perturbations listed. Anomalies in column ozone from 1.2-100 hPa due to the HTHH eruption include widespread O3 reductions in SH midlatitudes and O3 increases in the tropics, with peak anomalies in 15° latitude-binned, monthly averages of approximately -7% and +5%, respectively, occurring in austral spring. Using a 3-dimensional chemistry-climate-aerosol model and observational tracer correlations, changes in stratospheric composition are found to be due to both dynamical and chemical factors.

8.
Proc Natl Acad Sci U S A ; 120(46): e2313591120, 2023 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-37948586

RESUMO

The deleterious effects of ozone (O3) pollution on crop physiology, yield, and productivity are widely acknowledged. It has also been assumed that C4 crops with a carbon concentrating mechanism and greater water use efficiency are less sensitive to O3 pollution than C3 crops. This assumption has not been widely tested. Therefore, we compiled 46 journal articles and unpublished datasets that reported leaf photosynthetic and biochemical traits, plant biomass, and yield in five C3 crops (chickpea, rice, snap bean, soybean, and wheat) and four C4 crops (sorghum, maize, Miscanthus × giganteus, and switchgrass) grown under ambient and elevated O3 concentration ([O3]) in the field at free-air O3 concentration enrichment (O3-FACE) facilities over the past 20 y. When normalized by O3 exposure, C3 and C4 crops showed a similar response of leaf photosynthesis, but the reduction in chlorophyll content, fluorescence, and yield was greater in C3 crops compared with C4 crops. Additionally, inbred and hybrid lines of rice and maize showed different sensitivities to O3 exposure. This study quantitatively demonstrates that C4 crops respond less to elevated [O3] than C3 crops. This understanding could help maintain cropland productivity in an increasingly polluted atmosphere.


Assuntos
Oryza , Ozônio , Fotossíntese/fisiologia , Clorofila , Folhas de Planta/fisiologia , Poaceae , Zea mays/fisiologia , Produtos Agrícolas/genética , Oryza/genética , Dióxido de Carbono/farmacologia
9.
Proc Natl Acad Sci U S A ; 120(22): e2211432120, 2023 May 30.
Artigo em Inglês | MEDLINE | ID: mdl-37216559

RESUMO

The rapid melting of Arctic sea ice is the largest and clearest signal of anthropogenic climate change. Current projections indicate that the first ice-free Arctic summer will likely occur by mid-century, owing to increasing carbon dioxide concentrations in the atmosphere. However, other powerful greenhouse gases have also contributed to Arctic sea ice loss, notably ozone-depleting substances (ODSs). In the late 1980s, ODSs became strictly regulated by the Montreal Protocol, and their atmospheric concentrations have been declining since the mid-1990s. Here, analyzing new climate model simulations, we demonstrate that the Montreal Protocol, designed to protect the ozone layer, is delaying the first appearance of an ice-free Arctic summer, by up to 15 y, depending on future emissions. We also show that this important climate mitigation stems entirely from the reduced greenhouse gas warming from the regulated ODSs, with the avoided stratospheric ozone losses playing no role. Finally, we estimate that each Gg of averted ODS emissions results in approximately 7 km2 of avoided Arctic sea ice loss.

10.
Proc Natl Acad Sci U S A ; 120(32): e2207081120, 2023 08 08.
Artigo em Inglês | MEDLINE | ID: mdl-37523550

RESUMO

We assess wheat yield losses occurring due to ozone pollution in India and its economic burden on producers, consumers, and the government. Applying an ozone flux-based risk assessment, we show that ambient ozone levels caused a mean 14.18% reduction in wheat yields during 2008 to 2012. Furthermore, irrigated wheat was particularly sensitive to ozone-induced yield losses, indicating that ozone pollution could undermine climate-change adaptation efforts through irrigation expansion. Applying an economic model, we examine the effects of a counterfactual, "pollution-free" scenario on yield losses, wheat prices, consumer and producer welfare, and government costs. We explore three policy scenarios in which the government support farmers at observed levels of either procurement prices (fixed-price), procurement quantities (fixed-procurement), or procurement expenditure (fixed-expenditure). In pollution-free conditions, the fixed-price scenario absorbs the fall in prices, thus increasing producer welfare by USD 2.7 billion, but total welfare decreases by USD 0.24 billion as government costs increase (USD 2.9 billion). In the fixed-procurement and fixed-expenditure scenarios, ozone mitigation allows wheat prices to fall by 38.19 to 42.96%. The producers lose by USD 5.10 to 6.01 billion, but the gains to consumers and governments (USD 8.7 to 10.2 billion) outweigh these losses. These findings show that the government and consumers primarily bear the costs of ozone pollution. For pollution mitigation to optimally benefit wheat production and maximize social welfare, new approaches to support producers other than fixed-price grain procurement may be required. We also emphasize the need to consider air pollution in programs to improve agricultural resilience to climate change.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , Ozônio , Humanos , Ozônio/análise , Triticum , Poluentes Atmosféricos/análise , Governo
11.
Proc Natl Acad Sci U S A ; 120(27): e2303048120, 2023 Jul 04.
Artigo em Inglês | MEDLINE | ID: mdl-37364123

RESUMO

This paper formulates the cosmic ray-driven electron-induced reaction as a universal mechanism to provide a quantitative understanding of global ozone depletion. Based on a proposed electrostatic bonding mechanism for charge-induced adsorption of molecules on surfaces and on the measured dissociative electron transfer (DET) cross sections of ozone-depleting substances (ODSs) adsorbed on ice, an analytical equation is derived to give atmospheric chlorine atom concentration: [Formula: see text] where Φe is the prehydrated electron (epre-) flux produced by cosmic ray ionization on atmospheric particle surfaces, [Formula: see text] is the surface coverage of an ODS, and ki is the ODS's effective DET coefficient that is the product of the DET cross section, the lifetimes of surface-trapped epre- and Cl-, and the particle surface area density. With concentrations of ODSs as the sole variable, our calculated results of time-series ozone depletion rates in global regions in the 1960s, 1980s, and 2000s show generally good agreement with observations, particularly with ground-based ozonesonde data and satellite-measured data over Antarctica and with satellite data in a narrow altitude band at 13 to 20 km of the tropics. Good agreements with satellite data in the Arctic and midlatitudes are also found. A previously unreported effect of denitrification on ozone loss is found and expressed quantitatively. But this equation overestimates tropospheric ozone loss at northern midlatitudes and the Arctic, likely due to increased ozone production by the halogen chemistry in polluted regions. The results render confidence in applying the equation to achieve a quantitative understanding of global ozone depletion.

12.
Trends Biochem Sci ; 46(12): 992-1002, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34303585

RESUMO

Tropospheric ozone (O3) is among the most damaging air pollutant to plants. Plants alter the atmospheric O3 concentration in two distinct ways: (i) by the emission of volatile organic compounds (VOCs) that are precursors of O3; and (ii) by dry deposition, which includes diffusion of O3 into vegetation through stomata and destruction by nonstomatal pathways. Isoprene, monoterpenes, and higher terpenoids are emitted by plants in quantities that alter tropospheric O3. Deposition of O3 into vegetation is related to stomatal conductance, leaf structural traits, and the detoxification capacity of the apoplast. The biochemical fate of O3 once it enters leaves and reacts with aqueous surfaces is largely unknown, but new techniques for the tracking and identification of initial products have the potential to open the black box.


Assuntos
Poluentes Atmosféricos , Ozônio , Compostos Orgânicos Voláteis , Poluentes Atmosféricos/análise , Poluentes Atmosféricos/metabolismo , Poluentes Atmosféricos/farmacologia , Ozônio/análise , Ozônio/metabolismo , Ozônio/farmacologia , Folhas de Planta/metabolismo , Plantas/metabolismo , Compostos Orgânicos Voláteis/metabolismo , Compostos Orgânicos Voláteis/farmacologia
13.
Plant J ; 119(4): 1830-1843, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38924220

RESUMO

Tropospheric ozone [O3] is a secondary air pollutant formed from the photochemical oxidation of volatile organic compounds in the presence of nitrogen oxides, and it is one of the most damaging air pollutants to crops. O3 entry into the plant generates reactive oxygen species leading to cellular damage and oxidative stress, leading to decreased primary production and yield. Increased O3 exposure has also been shown to have secondary impacts on plants by altering the incidence and response to plant pathogens. We used the Capsicum annum (pepper)-Xanthomonas perforans pathosystem to investigate the impact of elevated O3 (eO3) on plants with and without exposure to Xanthomonas, using a disease-susceptible and disease-resistant pepper cultivar. Gas exchange measurements revealed decreases in diurnal photosynthetic rate (A') and stomatal conductance ( g s ' ), and maximum rate of electron transport (Jmax) in the disease-resistant cultivar, but no decrease in the disease-susceptible cultivar in eO3, regardless of Xanthomonas presence. Maximum rates of carboxylation (Vc,max), midday A and gs rates at the middle canopy, and decreases in aboveground biomass were negatively affected by eO3 in both cultivars. We also observed a decrease in stomatal sluggishness as measured through the Ball-Berry-Woodrow model in all treatments in the disease-resistant cultivar. We hypothesize that the mechanism conferring disease resistance to Xanthomonas in pepper also renders the plant less tolerant to eO3 stress through changes in stomatal responsiveness. Findings from this study help expand our understanding of the trade-off of disease resistance with abiotic stresses imposed by future climate change.


Assuntos
Capsicum , Ozônio , Fotossíntese , Doenças das Plantas , Xanthomonas , Capsicum/microbiologia , Capsicum/fisiologia , Capsicum/efeitos dos fármacos , Ozônio/farmacologia , Fotossíntese/efeitos dos fármacos , Xanthomonas/fisiologia , Xanthomonas/efeitos dos fármacos , Doenças das Plantas/microbiologia , Resistência à Doença , Estresse Fisiológico
14.
Proc Natl Acad Sci U S A ; 119(7)2022 02 15.
Artigo em Inglês | MEDLINE | ID: mdl-35131938

RESUMO

The catalytic depletion of Antarctic stratospheric ozone is linked to anthropogenic emissions of chlorine and bromine. Despite its larger ozone-depleting efficiency, the contribution of ocean-emitted iodine to ozone hole chemistry has not been evaluated, due to the negligible iodine levels previously reported to reach the stratosphere. Based on the recently observed range (0.77 ± 0.1 parts per trillion by volume [pptv]) of stratospheric iodine injection, we use the Whole Atmosphere Community Climate Model to assess the role of iodine in the formation and recent past evolution of the Antarctic ozone hole. Our 1980-2015 simulations indicate that iodine can significantly impact the lower part of the Antarctic ozone hole, contributing, on average, 10% of the lower stratospheric ozone loss during spring (up to 4.2% of the total stratospheric column). We find that the inclusion of iodine advances the beginning and delays the closure stages of the ozone hole by 3 d to 5 d, increasing its area and mass deficit by 11% and 20%, respectively. Despite being present in much smaller amounts, and due to faster gas-phase photochemical reactivation, iodine can dominate (∼73%) the halogen-mediated lower stratospheric ozone loss during summer and early fall, when the heterogeneous reactivation of inorganic chlorine and bromine reservoirs is reduced. The stratospheric ozone destruction caused by 0.77 pptv of iodine over Antarctica is equivalent to that of 3.1 (4.6) pptv of biogenic very short-lived bromocarbons during spring (rest of sunlit period). The relative contribution of iodine to future stratospheric ozone loss is likely to increase as anthropogenic chlorine and bromine emissions decline following the Montreal Protocol.


Assuntos
Atmosfera/análise , Iodo/química , Perda de Ozônio , Ozônio Estratosférico/química , Poluentes Atmosféricos/química , Regiões Antárticas , Estações do Ano
15.
Proc Natl Acad Sci U S A ; 119(35): e2207889119, 2022 08 30.
Artigo em Inglês | MEDLINE | ID: mdl-35994640

RESUMO

Since about 1980, the tropical Pacific has been anomalously cold, while the broader tropics have warmed. This has caused anomalous weather in midlatitudes as well as a reduction in the apparent sensitivity of the climate associated with enhanced low-cloud abundance over the cooler waters of the eastern tropical Pacific. Recent modeling work has shown that cooler temperatures over the Southern Ocean around Antarctica can lead to cooler temperatures over the eastern tropical Pacific. Here we suggest that surface wind anomalies associated with the Antarctic ozone hole can cause cooler temperatures over the Southern Ocean that extend into the tropics. We use the short-term variability of the Southern Annular Mode of zonal wind variability to show an association between surface zonal wind variations over the Southern Ocean, cooling over the Southern Ocean, and cooling in the eastern tropical Pacific. This suggests that the cooling of the eastern tropical Pacific may be associated with the onset of the Antarctic ozone hole.


Assuntos
Mudança Climática , Clima , Perda de Ozônio , Regiões Antárticas , Temperatura Baixa , Ozônio/análise , Oceano Pacífico , Temperatura , Tempo (Meteorologia) , Vento
16.
Proc Natl Acad Sci U S A ; 119(16): e2117399119, 2022 04 19.
Artigo em Inglês | MEDLINE | ID: mdl-35412909

RESUMO

The hydroxyl radical (OH) is the most important oxidant on global and local scales in the troposphere. Urban OH controls the removal rate of primary pollutants and triggers the production of ozone. Interannual trends of OH in urban areas are not well documented or understood due to the short lifetime and high spatial heterogeneity of OH. We utilize machine learning with observational inputs emphasizing satellite remote sensing observations to predict surface OH in 49 North American cities from 2005 to 2014. We observe changes in the summertime OH over one decade, with wide variation among different cities. In 2014, compared to the summertime OH in 2005, 3 cities show a significant increase of OH, whereas, in 27 cities, OH decreases in 2014. The year-to-year variation of OH is mapped to the decline of the NO2 column. We conclude that these cities in this analysis are either in the NOx-limited regime or at the transition from a NOx suppressed regime to a NOx-limited regime. The result emphasizes that, in the future, controlling NOx emissions will be most effective in regulating the ozone pollution in these cities.


Assuntos
Poluentes Atmosféricos , Radical Hidroxila , Ozônio , Poluentes Atmosféricos/análise , Atmosfera , Cidades , Monitoramento Ambiental , Radical Hidroxila/análise , América do Norte , Ozônio/análise
17.
Proc Natl Acad Sci U S A ; 119(10): e2117325119, 2022 03 08.
Artigo em Inglês | MEDLINE | ID: mdl-35238658

RESUMO

SignificanceLarge wildfires have been observed to inject smoke into the stratosphere, raising questions about their potential to affect the stratospheric ozone layer that protects life on Earth from biologically damaging ultraviolet radiation. Multiple observations of aerosol and NO2 concentrations from three independent satellite instruments are used here together with model calculations to identify decreases in stratospheric NO2 concentrations following major Australian 2019 through 2020 wildfires. The data confirm that important chemistry did occur on the smoke particle surfaces. The observed behavior in NO2 with increasing particle concentrations is a marker for surface chemistry that contributes to midlatitude ozone depletion. The results indicate that increasing wildfire activity in a warming world may slow the recovery of the ozone layer.


Assuntos
Altitude , Material Particulado/química , Fumaça/análise , Ozônio Estratosférico/química , Incêndios Florestais , Austrália
18.
Proc Natl Acad Sci U S A ; 119(37): e2201213119, 2022 Sep 13.
Artigo em Inglês | MEDLINE | ID: mdl-36067322

RESUMO

Atmospheric electrical discharges are now known to generate unexpectedly large amounts of the atmosphere's primary oxidant, hydroxyl (OH), in thunderstorm anvils, where electrical discharges are caused by atmospheric charge separation. The question is "Do other electrical discharges also generate large amounts of oxidants?" In this paper, we demonstrate that corona formed on grounded metal objects under thunderstorms produce extreme amounts of OH, hydroperoxyl (HO2), and ozone (O3). Hundreds of parts per trillion to parts per billion of OH and HO2 were measured during seven thunderstorms that passed over the rooftop site during an air quality study in Houston, TX in summer 2006. A combination of analysis of these field results and laboratory experiments shows that these extreme oxidant amounts were generated by corona on the inlet of the OH-measuring instrument and that corona are easier to generate on lightning rods than on the inlet. In the laboratory, increasing the electric field increased OH, HO2, and O3, with 14 times more O3 generated than OH and HO2, which were equal. Calculations show that corona on lightning rods can annually generate OH that is 10-100 times ambient amounts within centimeters of the lightning rod and on high-voltage electrical power lines can generate OH that is 500 times ambient a meter away from the corona. Contrary to current thinking, previously unrecognized corona-generated OH, not corona-generated UV radiation, mostly likely initiates premature degradation of high-voltage polymer insulators.

19.
Am J Respir Cell Mol Biol ; 70(6): 493-506, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38386777

RESUMO

Lung inflammation, caused by acute exposure to ozone (O3), one of the six criteria air pollutants, is a significant source of morbidity in susceptible individuals. Alveolar macrophages (AMØs) are the most abundant immune cells in the normal lung, and their number increases after O3 exposure. However, the role of AMØs in promoting or limiting O3-induced lung inflammation has not been clearly defined. In this study, we used a mouse model of acute O3 exposure, lineage tracing, genetic knockouts, and data from O3-exposed human volunteers to define the role and ontogeny of AMØs during acute O3 exposure. Lineage-tracing experiments showed that 12, 24, and 72 hours after exposure to O3 (2 ppm) for 3 hours, all AMØs were of tissue-resident origin. Similarly, in humans exposed to filtered air and O3 (200 ppb) for 135 minutes, we did not observe at ∼21 hours postexposure an increase in monocyte-derived AMØs by flow cytometry. Highlighting a role for tissue-resident AMØs, we demonstrate that depletion of tissue-resident AMØs with clodronate-loaded liposomes led to persistence of neutrophils in the alveolar space after O3 exposure, suggesting that impaired neutrophil clearance (i.e., efferocytosis) leads to prolonged lung inflammation. Moreover, depletion of tissue-resident AMØs demonstrated reduced clearance of intratracheally instilled apoptotic Jurkat cells, consistent with reduced efferocytosis. Genetic ablation of MerTK (MER proto-oncogene, tyrosine kinase), a key receptor involved in efferocytosis, also resulted in impaired clearance of apoptotic neutrophils after O3 exposure. Overall, these findings underscore the pivotal role of tissue-resident AMØs in resolving O3-induced inflammation via MerTK-mediated efferocytosis.


Assuntos
Macrófagos Alveolares , Ozônio , Fagocitose , Proto-Oncogene Mas , c-Mer Tirosina Quinase , Ozônio/farmacologia , c-Mer Tirosina Quinase/metabolismo , c-Mer Tirosina Quinase/genética , Animais , Macrófagos Alveolares/metabolismo , Macrófagos Alveolares/efeitos dos fármacos , Humanos , Fagocitose/efeitos dos fármacos , Camundongos , Camundongos Endogâmicos C57BL , Pneumonia/metabolismo , Pneumonia/induzido quimicamente , Pneumonia/patologia , Camundongos Knockout , Masculino , Inflamação/metabolismo , Inflamação/patologia , Inflamação/induzido quimicamente , Apoptose/efeitos dos fármacos , Pulmão/patologia , Pulmão/metabolismo , Pulmão/efeitos dos fármacos , Eferocitose
20.
J Lipid Res ; 65(9): 100630, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-39182607

RESUMO

The pulmonary system represents a unique lipidomic environment as it contains cellular membrane-bound lipid species and a specialized reservoir of lipids in the airway epithelial lining fluid. As a major initial point of defense, airway lipids react to inhaled contaminants such as volatile organic compounds, oxides of nitrogen, or ozone (O3), creating lipokine signaling that is crucial for both the initiation and resolution of inflammation within the lung. Dietary modulation of eicosanoids has gained increased attention in recent years for improvements to cardiovascular health. The current study sought to examine how dietary supplementation with eicosanoid precursors (i.e, oils rich in saturated or polyunsaturated fatty acids) might alter the lung lipid composition and subsequently modify the inflammatory response to ozone inhalation. Our study demonstrated that mice fed a diet high in saturated fatty acids resulted in diet-specific changes to lung lipid profiles and increased cellular recruitment to the lung following ozone inhalation. Bioinformatic analysis revealed an ozone-dependent upregulation of several lipid species, including phosphoserine 37:5. Pathway analysis of lipid species revealed the process of lateral diffusion of lipids within membranes to be significantly altered due to ozone exposure. These results show promising data for influencing pulmonary lipidomic profiles via diet, which may provide a pragmatic therapeutic approach to protect against lung inflammation and damage following pulmonary insult.


Assuntos
Pulmão , Ozônio , Animais , Ozônio/farmacologia , Camundongos , Pulmão/metabolismo , Pulmão/efeitos dos fármacos , Pulmão/patologia , Inflamação/metabolismo , Camundongos Endogâmicos C57BL , Masculino , Metabolismo dos Lipídeos/efeitos dos fármacos , Lipidômica , Lipídeos/análise
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