RESUMO
Introduction: Pathogenic link of dentofacial abnormalities with posture disturbance and vertebra deformation causes interest in researchers, because the problem of the disorder of skeletal system has an important role. Orthodontic correction of dentofacial abnormalities without treatment of skeletal apparatus is incorrect and it leads to the large number of relapses and complications and also including temporo-mandibular joint. The aim of the research was to study correlation between injuries of hard tissues of teeth, posture disorders, bite abnormalities (malocclusion) in schoolchildren with hearing disorders. Material and methods: The condition of hard tissues of teeth, muscoskeletal system, dentofacial system in pupils with hearing impairment was done and evaluated. The age of examined is 6-19 years old, bite formation: 1st presents the period of mixed bite (6-13 years old), 2nd presents the period of permanent bite (14-19 years old). Results: Results and conclusions: During dental examination it was detected that 58 pupils with hearing disorders (81,8%) have carious lesions of the teeth, the level of caries intensity contains 3,36. The condition of skeletal system was investigated in 56 pupils (36 boys and 20 girls). Disturbances of skeletal system in schoolchildren with hearing disorders presented 94,74%; 5,26% of pupils were almost healthy. The condition of the bite was examined in 58 pupils (32 boys and 26 girls). Different types of disorders of dentofacial apparatus were detected in 100% of pupils with hearing disorders. The most widespread pathology of bite was Angle's bite (the first class) 68,97%, the second class in 27,58%, the third class 3,45%. Orthognathic bite among pupils with hearing disorders was not observed. In 31,15% of pupils during temporo-mandibular joint, deviation of mandible is observed.
Assuntos
Perda Auditiva , Má Oclusão , Dente , Adolescente , Criança , Oclusão Dentária , Feminino , Humanos , Masculino , Mandíbula , Adulto JovemRESUMO
Objective: To review the research progress of mitochondrial dynamics mediated by optic atrophy 1 (OPA1) in skeletal system diseases. Methods: The literatures about OPA1-mediated mitochondrial dynamics in recent years were reviewed, and the bioactive ingredients and drugs for the treatment of skeletal system diseases were summarized, which provided a new idea for the treatment of osteoarthritis. Results: OPA1 is a key factor involved in mitochondrial dynamics and energetics and in maintaining the stability of the mitochondrial genome. Accumulating evidence indicates that OPA1-mediated mitochondrial dynamics plays an important role in the regulation of skeletal system diseases such as osteoarthritis, osteoporosis, and osteosarcoma. Conclusion: OPA1-mediated mitochondrial dynamics provides an important theoretical basis for the prevention and treatment of skeletal system diseases.