Data derived extrapolation factors (DDEFs) for rat to human interspecies extrapolation for the HPPD inhibitor mesotrione.

In the risk assessment of agrochemicals, there has been a historical paucity of using data to refine the default adjustment factors, even though large datasets are available to support this. The current state of the science for addressing uncertainty regarding animal to human extrapolation (AFA) is to develop a "data-derived" adjustment factor (DDEF) to quantify such differences, if data are available. Toxicokinetic (TK) and toxicodynamic (TD) differences between species can be utilized for the DDEF, with human datasets being ideal yet rare. We identified a case for a currently registered herbicide, mesotrione, in which human TK and TD are available. This case study outlines an approach for the development of DDEFs using comparative human and animal data and based on an adverse outcome pathway (AOP) for inhibition of 4-hydroxyphenol pyruvate dioxygenase (HHPD). The calculated DDEF for rat to human extrapolation (AFA) for kinetics (AFAK = 2.5) was multiplied by the AFA for dynamics (AFAD = 0.3) resulting in a composite DDEF of ∼1 (AFA = 0.75). This reflects the AOP and available scientific evidence that humans are less sensitive than rats to the effects of HPPD inhibitors. Further analyses were conducted utilizing in vitro datasets from hepatocytes and liver cytosols and extrapolated to whole animal using in vitro to in vivo extrapolation (IVIVE) to support toxicodynamic extrapolation. The in vitro datasets resulted in the same AFAD as derived for in vivo data (AFAD = 0.3). These analyses demonstrate that a majority of the species differences are related to toxicodynamics. Future work with additional in vitro/in vivo datasets for other HPPD inhibitors and cell types will further support this result. This work demonstrates utilization of all available toxicokinetic and toxicodynamic data to replace default uncertainty factors for agrochemical human health risk assessment.

Evolution origin analysis and health risk assessment of groundwater environment in a typical mining area: Insights from water-rock interaction and anthropogenic activities.

Coal mining changes groundwater environment, results in deterioration of water quality and endangering human health in the mining area. However, the comprehensive study of groundwater evolution and its potential impact in mining area is still insufficient. In this study, 95 groundwater samples were collected from 2019 to 2020 in a typical mining area of China. Ion ratio coefficients, isotopic tracing technology, Entropy-weighted water quality index (EWQI) and human health risk assessment model (HHRA) were applicated to investigate the hydrochemical variation reasons, groundwater quality and its potential health risk in the study area. Results showed that the groundwater hydrochemical types changed from HCO3∙SO4-Ca∙Mg type to SO4-Ca∙Mg and SO4∙Cl-Ca∙Mg type. Water-rock interaction, agricultural activities, manure and sewage input, precipitation and evaporation controlled the groundwater hydrochemical composition. Groundwater quality showed a trend of fluctuation with an average EWQI of 59.23, 68.92, 63.75, 58.02 and 64.92, respectively. 91.6% of the water samples was fair and acceptable for drinking. The groundwater health risk of nitrate in the study area ranged from 0.03 to 17.80. Infants had the highest health risk and nitrate concentration was the most sensitive parameter. The results will present a comprehensive research of groundwater evolution and potential impacts through a typical mining area example. Thereby offering valuable insights into the influencing factors identification, hydrochemical processes evolution, protection and utilization of groundwater in global mining areas.

Ecological and health risk assessments of heavy metals and their accumulation in a peanut-soil system.

Heavy metals pollution is a notable threat to environment and human health. This study evaluated the potential ecological and health risks of heavy metals (Cu, Cr, Cd, Pb, Zn, Ni, and As) and their accumulation in a peanut-soil system based on 34 soil and peanut kernel paired samples across China. Soil As and Cd posed the greatest pollution risk with 47.1% and 17.6% of soil samples exceeding the risk screen levels, respectively, with 26.5% and 20.6% of the soil sites at relatively strong potential ecological risk level, respectively, and with the geo-accumulation levels at several soil sites in the uncontaminated to moderately contaminated categories. About 35.29% and 2.94% of soil sites were moderately and severely polluted based on Nemerow comprehensive pollution index, respectively, and a total of 32.4% of samples were at moderate ecological hazard level based on comprehensive potential ecological risk index values. The Cd, Cr, Ni, and Cu contents exceeded the standard in 11.76, 8.82, 11.76 and 5.88% of the peanut kernel samples, respectively. Soil metals posed more health risks to children than adults in the order As > Ni > Cr > Cu > Pb > Zn > Cd for non-carcinogenic health risks and Ni > Cr â‰« Cd > As > Pb for carcinogenic health risks. The soil As non-cancer risk index for children was greater than the permitted limits at 14 sites, and soil Ni and Cr posed the greatest carcinogenic risk to adults and children at many soil sites. The metals in peanut did not pose a non-carcinogenic risk according to standard. Peanut kernels had strong enrichment ability for Cd with an average bio-concentration factor (BCF) of 1.62. Soil metals contents and significant soil properties accounted for 35-74% of the variation in the BCF values of metals based on empirical prediction models.

Heavy metals and trace minerals in commonly available shark species from North East Arabian Sea: A human health risk perspective.

Shark is a seafood commodity that is a good source of minerals and accumulates heavy metals and trace elements through biomagnification, which can pose health risk if taken above the permissible limit. A study was conducted on commonly landed eleven shark species (Scoliodon laticaudus, Rhizopriodon oligolinx, Sphyrna lewini (CR), Carcharhinus macloti, Carcharinus limbatus, Carcharhinus amblyrhynchoides, Carcharhinus sorrah, Carcharinus falciformes(VU), Glaucostegus granulatus, Chiloscyllium arabicum, Loxodon macrorhinus) and analyzed for their heavy metal content, Hazard Index, Total Hazard Quotient, Metal Pollution Index, and also calculated the health risk associated with the consumption. Most of the heavy metals and trace minerals were found to be within the acceptable limit. The Targeted Hazard Quotient (THQ) and the Hazard Index (HI) of all the species except two were less than 1 (HI ≤ 1.0). The Metal Pollution Index (MPI) is showing either no impact or very low contamination. An overall study on hazard identification and health risk characterization in terms of heavy metals shows contamination of some heavy metals in sharks, but there is no potential human health risk associated with consumption.

The hidden threat of heavy metal leaching in urban runoff: Investigating the long-term consequences of land use changes on human health risk exposure.

This study evaluated the potential effects of long-term land use and climate change on the quality of surface runoff and the health risks associated with it. The land use change projection 2030 was derived from the main changes in land use from 2009 to 2019, and rainfall data was obtained from the Long Ashton Research Station Weather Generator (LARS-WG) model. The Long-Term Hydrological Impact Assessment (L-THIA) model was then utilized to calculate the rate of runoff heavy metal (HM) pollutant loading from the urban catchment. It was found that areas with heavy development posed a significantly greater public health risk associated with runoff, with higher risks observed in high-development and traffic areas compared to industrial, residential, and commercial areas. Additionally, exposure to Lead (Pb), Mercury (Hg), and Arsenic (As) was found to contribute significantly to overall non-carcinogenic health risks for possible consumers of runoff. Carcinogenic risk values of As, Cadmium (Cd), and Pb were also observed to increase, particularly in high-development and traffic areas, by 2030. This investigation offers important insight into the health risks posed by metals present in surface runoff in urban catchment areas under different land use and climate change scenarios.

Can arsenic bioavailability be predicted in soils using in vitro gastro-intestinal simulation?

Many gastrointestinal simulation methods have been used to predict bioavailability, but the suitability of different methods for the same metal(loid)s varies widely, which inevitably affects the accuracy of human health risk assessment. Arsenic is a common and important contaminant in many contaminated land situations. It can be readily absorbed and has teratogenic and mutagenic toxicity. Therefore, in this study, four the most commonly used in vitro simulation methods (the Physiologically Based Extraction Test (PBET), In Vitro Gastrointestinal Method (IVG), Soluble Bioavailability Research Consortium (SBRC), the Unified BARGE Method (UBM)) were tested against an in vivo animal live model, to evaluate their effectiveness for the prediction of soil As bioavailability in 10 industrially contaminated soils. The soil As relative bioavailability (RBA) varied between 15% and 68% in the different soils. As bioaccessibility differed between the 4 gastro-intestinal simulation methods. Gastric phase of UBM (UBMG) predicted As relative bioavailability the best of the 4 assays (R2 = 0.81). This study provides theoretical and technical support to refine human health risk assessment of As in soils from urban industrial legacy contaminated sites.

Groundwater health risk assessment and its temporal and spatial evolution based on trapezoidal fuzzy number-Monte Carlo stochastic simulation: A case study in western Jilin province.

The United States Environmental Protection Agency (USEPA) Four-step-Method (FSM) is a straightforward and extensively utilized tool for evaluating regional health risks, However, the complex and heterogeneous groundwater environment system causes great uncertainty in the assessment process. Triangular stochastic simulation (TSS) possesses certain advantages in solving uncertainty problems, but its inadequacy with discrete data reveals limitations in this aspect. To solve the above problems, this study proposes to construct trapezoidal fuzzy number-Monte Carlo stochastic simulation (TFN-MCSS) to compensate for the shortcomings of the first two methods. This method adopted trapezoidal fuzzy number (TFN) analysis to comprehensively consider the characteristics of a large dispersion of water quality monitoring data and the uncertainty of the human health risk assessment (HHRA) process. Concurrently, to overcome the subjectivity and uncertainty of artificially determining the interval of TFN in traditional methods, the slope was used to select the most probable interval value (TMPIV) of TFN combined with the α-truncated set technique (α-TST) and MCSS. Based on these, a TFN-MCSS was constructed and applied to groundwater HHRA in western Jilin Province. First, the groundwater chemical characteristic determination and water quality evaluation in western Jilin were performed to identify the main pollution indicators, and the health risk effects of pollutants in groundwater of different aquifers at different time periods on adults and children were evaluated using the TFN-MCSS. The uncertainty and sensitivity were analyzed, and the primary risk control indicators were identified and compared to FSM and TSS. The results reveal that TFN-MCSS was more sensitive to data and could reduce the uncertainty of assessment process. It indicated that over a 10-year period, the health risks associated with unconfined groundwater (UW) and confined water (CW) decreased by greater than 52 %. However, the highest total non-carcinogenic risk index (THI) was 1.3-fold higher than the safety threshold, and this posed a health risk.

Determination and risk assessment of heavy metals in raw foodstuffs sold from open markets in Zambia; a comparison of Kabwe, Kitwe, and Lusaka towns.

The research focused on risk assessment of some heavy metals in common vegetables and fish sold on open markets in three towns of Zambia. The mean level of heavy metals ranged as follows (mg/kg): 1.9 to 662.7, 3.0 to 3472.3 and 2.0 to 1698.7 of cadmium (lowest) and aluminium (highest) for samples from Kabwe, Kitwe and Lusaka, respectively. Statistical analysis indicated that the concentrations of samples from Kitwe and Lusaka towns were similar, P > 0.05. However, there were noteworthy differences in the mean amounts of heavy metals in samples from Kitwe and Kabwe, and samples from Kabwe and Lusaka towns, P < .0167. The health risk analysis indicates possible non-carcinogenic and carcinogenic risks to the consumer. This is because the hazard index (HI) for all metals in all samples from all towns was greater than 1 and the cancer risk (CR) for cadmium was above 10-4 in all samples from all towns.

Dietary exposure to polycyclic aromatic hydrocarbons-contaminated Talinum Triangulare grown along polluted river.

The research aims to evaluate the source, dispersion, and human health risk assessment of PAH-contaminated Talinum Triangulare grown along the polluted Ikpoba River. The freeze-dried vegetables were sonicated with dichloromethane for an hour and then concentrated using a rotary evaporator. The extract was purified using a glass column with anhydrous Na2SO4 and silica gel and analyzed using gas chromatography-mass spectrometry (GC-MS). The distribution of the contaminants showed that Pyrene < Benzo(a)anthracene ≤ Fluorene < Phenathrene ≤ Naphthalene ≤ Acenaphthene < Anthracene ≤ Acenaphthylene, while Pyrene < Benzo(a)anthracene < Fluorene < Phenathrene < Acenaphthalene ≤ Naphthalene < Anthracene < Acenaphthylene in wet and dry periods, respectively. The average ∑8 PAHs was 0.85 mg/kg and 0.75 mg/kg in wet and dry periods, respectively, and showed a decrease of 17.64% from wet to dry periods. The daily average dose revealed that the infant male and the adult female consumed the least and highest doses of T. Triangulare (TT), respectively. Furthermore, the hazard quotient and hazard index were < 1 for all the target groups, with adult females having higher values in both seasons. However, the incremental life cancer risk of the target group was between potential and high-potential cancer risk, with adolescent males and adult females more prone to low and high cancer risk, respectively. The isomer ratio and multivariate statistics revealed the sources of the PAH-contaminated TT to be more from pyrolysis.

Evaluation of potential human health risks arising from nitrate and fluoride in the groundwater of Aurangabad, Bihar using GIS and chemometric analysis.

This study employed the groundwater pollution index to assess the appropriateness of groundwater for human consumption. Additionally, the hazard index was utilized to evaluate the potential non-carcinogenic risks associated with fluoride and nitrate exposure among children, women, and men in the study region. A total of 103 samples were collected from the Aurangabad district of Bihar. The analyzed samples were assessed using several physicochemical parameters. Major cations in the groundwater are Ca2+ > Mg2+ and major anions are HCO3- > Cl- > SO42- > NO3- > F- > PO43-. Around 17% of the collected groundwater samples surpassed the allowable BIS concentration limits for Nitrate, while approximately 11% surpassed the allowed limits for fluoride concentration. Principal component analysis was utilized for its efficacy and efficiency in the analytical procedure. Four principal components were recovered that explained 69.06% of the total variance. The Hazard Quotient (HQ) of nitrate varies between 0.03-1.74, 0.02-1.47, and 0.03-1.99 for females, males, and children, respectively. The HQ of fluoride varies between 0.04-1.59, 0.04-1.34, and 0.05-1.82 for females, males, and children, respectively. The central part of the district was at high risk according to the spatial distribution maps of the total hazard index (THI). Noncarcinogenic risks due to THI are 47%, 37%, and 28% for children, females, and males, respectively. According to the human health risk assessment, children are more prone to getting affected by polluted water than adults. The groundwater pollution index (GPI) value ranges from 0.46 to 2.27 in the study area. Seventy-five percent of the samples fell under minor pollution and only one fell under high pollution. The spatial distribution of GPI in the research area shows that the central region is highly affected, which means that this water is unsuitable for drinking purposes.

Potentially toxic metals in seawater, sediment and seaweeds: bioaccumulation, ecological and human health risk assessment.

This study assesses the bioaccumulation, ecological, and health risks associated with potentially toxic metals (PTMs), including Pb, Hg, Cd, As, and Cr in Hare Island, Thoothukudi. The results revealed that the concentration of PTMs in sediment, seawater, and S. wightii ranged from 0.095 to 2.81 mg kg-1, 0.017 to 1.515 mg L-1, and 0.076 to 5.713 mg kg-1, respectively. The highest concentrations of PTMs were found in the S. wightii compared to seawater and sediment. The high bioaccumulation of Hg and As in S. wightii suggests that it can be used as a bioindicator for these elements in this region. The ecological risk indices, which include individual, complex, biological, and ecological pollution indices, suggest that Hare Island had moderate contamination with Hg and Cd. However, there are no human health risks associated with PTMs. This study examines the current ecological and health risks associated with PTMs and emphasizes the importance of regular monitoring.

Potentially toxic elements contamination in the water resources: an integrated risk assessment approach in the upper Citarum watershed area.

The Citarum watershed is West Java Province's most important water resource; hence, harmful compounds should be monitored regularly. This study assessed pollution levels along with ecological and health risks from Cd, Pb, Mn, Fe, Cu, Cr, and Hg contamination in river water, sediment, groundwater, and soil in Citarum's upper watershed. In river water, the average amounts of Cd, Pb, Mn, Fe, Cu, Cr, and Hg were 0.002, 0.05, 0.092, 0.649, 0.022, 0.001, and 0.421 mg/L. In sediment, they were 7.4, 1175.1, 32,289.9, 37.3, 3.9, and 0.015 mg/kg. The mean concentrations of Cd, Pb, Mn, Fe, Cu, Cr, and Hg in groundwater were 0.004, 0.046, 0.567, 0.366, 0.019, 0.001, and 0.177 mg/L, and in soil, BDL, 10.2, 744.6, 50,094.1, 45.6, 5.9, and 0.015 mg/kg. The river water and groundwater were highly polluted by PTEs, with HPI values of 14,733 and 933, respectively. While PTEs pollution levels and risk in sediment and soil were low based on I-geo, CF, PLI, and M-ERM-Q values, PTEs contamination in river water may cause adverse impacts on aquatic living organisms (HQ > 1). The population doing recreational activities in river ecosystems was still safe from non-carcinogenic and carcinogenic impacts due to PTEs exposure from river water and sediment (THI < 1 and TCR value < 1E-04), while the population in the upper Citarum River was not safe from the carcinogenic risk due to PTE exposure from groundwater and soil (TCR > 1E-04). The sensitivity analysis showed that Cd concentration in groundwater is the most influential factor in cancer risk, with a total contribution of 99.9%. Therefore, a reduction in Cd concentration in groundwater is important to reduce cancer risk in the population.

Is the 90-day dog study necessary for pesticide toxicity testing?

When registering a new pesticide, 90-day oral toxicity studies performed with both rodent and non-rodent species, typically rats and dogs, are part of a standard battery of animal tests required in most countries for human health risk assessment (RA). This analysis set out to determine the need for the 90-day dog study in RA by reviewing data from 195 pesticides evaluated by the US Environmental Protection Agency (USEPA) from 1998 through 2021. The dog study was used in RA for only 42 pesticides, mostly to set the point of departure (POD) for shorter-term non-dietary pesticide exposures. Dog no-observed-adverse-effect-levels (NOAELs) were lower than rat NOAELs in 90-day studies for 36 of the above 42 pesticides, suggesting that the dog was the more sensitive species. However, lower NOAELs may not necessarily correspond to greater sensitivity as factors such as dose spacing and/or allometric scaling need to be considered. Normalizing doses between rats and dogs explained the lower NOAELs in 22/36 pesticides, indicating that in those cases the dog was not more sensitive, and the comparable rat study could have been used instead for RA. For five of the remaining pesticides, other studies of appropriate duration besides the 90-day rat study were available that would have offered a similar level of protection if used to set PODs. In only nine cases could no alternative be found in the pesticide's database to use in place of the 90-day dog study for setting safe exposure levels or to identify unique hazards. The present analysis demonstrates that for most pesticide risk determinations the 90-day dog study provided no benefit beyond the rat or other available data.

Application of probabilistic methods to address variability and uncertainty in estimating risks for non-cancer health effects.

Human health risk assessment currently uses the reference dose or reference concentration (RfD, RfC) approach to describe the level of exposure to chemical hazards without appreciable risk for non-cancer health effects in people. However, this "bright line" approach assumes that there is minimal risk below the RfD/RfC with some undefined level of increased risk at exposures above the RfD/RfC and has limited utility for decision-making. Rather than this dichotomous approach, non-cancer risk assessment can benefit from incorporating probabilistic methods to estimate the amount of risk across a wide range of exposures and define a risk-specific dose. We identify and review existing approaches for conducting probabilistic non-cancer risk assessments. Using perchloroethylene (PCE), a priority chemical for the U.S. Environmental Protection Agency under the Toxic Substances Control Act, we calculate risk-specific doses for the effects on cognitive deficits using probabilistic risk assessment approaches. Our probabilistic risk assessment shows that chronic exposure to 0.004 ppm PCE is associated with approximately 1-in-1,000 risk for a 5% reduced performance on the Wechsler Memory Scale Visual Reproduction subtest with 95% confidence. This exposure level associated with a 1-in-1000 risk for non-cancer neurocognitive deficits is lower than the current RfC for PCE of 0.0059 ppm, which is based on standard point of departure and uncertainty factor approaches for the same neurotoxic effects in occupationally exposed adults. We found that the population-level risk of cognitive deficit (indicating central nervous system dysfunction) is estimated to be greater than the cancer risk level of 1-in-100,000 at a similar chronic exposure level. The extension of toxicological endpoints to more clinically relevant endpoints, along with consideration of magnitude and severity of effect, will help in the selection of acceptable risk targets for non-cancer effects. We find that probabilistic approaches can 1) provide greater context to existing RfDs and RfCs by describing the probability of effect across a range of exposure levels including the RfD/RfC in a diverse population for a given magnitude of effect and confidence level, 2) relate effects of chemical exposures to clinical disease risk so that the resulting risk assessments can better inform decision-makers and benefit-cost analysis, and 3) better reflect the underlying biology and uncertainties of population risks.

A new approach methodology using kinetically-derived maximum dose levels in risk assessment - A case study with afidopyropen.

We present a case study for afidopyropen (AF; insecticide) to characterize chronic dietary human health risk using a Risk 21-based approach. Our objective is to use a well-tested pesticidal active ingredient (AF) to show how a new approach methodology (NAM), using the kinetically-derived maximum dose (KMD) and with far less animal testing, can reliably identify a health-protective point of departure (PoD) for chronic dietary human health risk assessments (HHRA). Chronic dietary HHRA involves evaluation of both hazard and exposure information to characterize risk. Although both are important, emphasis has been placed on a checklist of required toxicological studies for hazard characterization, with human exposure information only considered after evaluation of hazard data. Most required studies are not used to define the human endpoint for HHRA. The information presented demonstrates a NAM that uses the KMD determined by saturation of a metabolic pathway, which can be used as an alternative POD. In these cases, the full toxicological database may not need to be generated. Demonstration that the compound is not genotoxic and that the KMD is protective of adverse effects in 90-day oral rat and reproductive/developmental studies is sufficient to support the use of the KMD as an alternative POD.

A novel regional-scale human health risk assessment model for soil heavy metal(loid) pollution based on empirical Bayesian kriging.

Soil heavy metal(loid)s contamination caused by rapid urbanization and industrialization seriously affects human health and hinders the global sustainable development goals (SDGs). Currently, there is a lack of comprehensive human health risk assessment (HHRA) studies for multiple land use types at the regional scale. We propose a practical risk assessment framework that integrates empirical Bayesian kriging (EBK), pollution level analyses, and modified HHRA modeling. The concentrations of copper industry-related metals (Cu, Ni, Cd, As, and Hg) in 332 topsoil samples from the south bank of the Yangtze River in Tongling were investigated. Obvious enrichment of Cu, Cd, As, and Hg was detected, and the average concentration of Cu was 5.24 times higher than the background values. The distribution of heavy metal(loid) pollution was typically high in the south and east, and low in the north and west. The mean errors of interpolation for Cu, Ni, and Hg were 0.84, 1.29, and 0, respectively, and the root mean square errors of interpolation for Cd and As were 1.29 and 0.86, respectively. Non-carcinogenic risks of soil heavy metal(loid)s were assessed as acceptable throughout the studied area. The hazard index decreased in the order As (0.448) > Ni (0.0729) > Cd (0.0136) > Hg (9.04 ×10-4) > Cu (6.41 ×10-4). Nevertheless, the carcinogenic risks of Ni, Cd, and As in 70-80% of the administrative units (AUs) were between 10-6 to 10-4, considered an unacceptable level. Exposure through the oral ingestion route accounted for 88.0-99.2% of the total three exposure routes. It is worth noting that four AUs were considered to be the priority control units, and Ni and As were identified as the priority control soil heavy metal(loid)s. This case demonstrates the feasibility and scientific validity of the new EBK-HHRA framework, which confirms that EBK can effectively predict the spatial distribution patterns of soil heavy metal(loid)s and that modified HHRA models are conducive to risk integration at the regional scale. The EBK-HHRA approach is generic and provides substantial support for risk source identification and risk management of soil heavy metal(loid)s contamination at the regional scale.

Incorporating oral, inhalation and dermal bioaccessibility into human health risk characterization following exposure to Chromated Copper Arsenate (CCA)-contaminated soils.

Exposure to potentially toxic metal(loid)s (PTMs) in soil may happen via ingestion, inhalation, and dermal pathway. A more accurate risk characterization should consider PTM bioavailability. Using ten soil samples collected in the Montreal area (Canada) near CCA-treated utility poles, this study aims to characterize non-carcinogenic and carcinogenic human health risks associated with As, Cr, Cu, Pb, and Zn through a multi-pathway exposure approach. This innovative study incorporates, for the first time, the bioaccessible fraction of the metal(loid)s for three exposure routes and two different scenarios. For the residential and industrial scenarios, the oral and dermal pathways yielded a hazard index (HI) much higher than 1 with and without bioaccessibility considerations (range 1.7 - 349 without bioaccessibility and 0.8-134 with bioaccessibility), whereas the inhalation pathway caused a lower hazard (HI < 1). For the dermal pathway, the hazard quotient was higher when bioaccessibility of field-collected samples was considered due to inherent assumptions from the US EPA soil approach to calculate the dermal dose. For carcinogenic risk, As and Pb were the most significant contributors to risk for the oral pathway, followed by the same elements for the dermal pathway. The overall carcinogenic risk was higher than the acceptable risk ( > 10-4) with and without bioaccessibility considerations (range 1.9E-4 - 9.6E-3 without bioaccessibility and 6.8E-5 - 3.8E-3 with bioaccessibility). Bioaccessibility tests provide a more accurate assessment of exposure to PTMs compared to total concentrations in soils.

Spatial distribution of heavy metals in soils around cement factory and health risk assessment: a case study of Canakkale-Ezine (NW Turkey).

Sustainable use of agricultural land plays a crucial role in ensuring food security. For sustainable use of soils, it is very important to focus on the pollution status. This study was conducted on the soils in the northern part of the Ezine district in northwestern Turkey. The study aimed to determine the physicochemical properties of the soils in the vicinity of the cement plant, the concentrations of heavy metals, the spatial distribution of heavy metals, and their impact on the health of the local human population. Soil samples were collected from the cement plant in different directions (S,W, N, E, NE, SW) and at different distances (1, 3, 5, and 7 km) from 0-10 cm depth with three replicates. The soil samples were analyzed for texture, pH, electrical conductivity, lime, and heavy metals such as Cd, Co, Cu, Fe, Mn, Ni, Pb, and Zn. The soils had different textures (loam, sandy clay loam, loam, sandy loam), slightly alkaline pH, low lime content, and moderate organic matter content. Except for Cd and Pb, the average values of the other heavy metals (Co = 1.18 < 19 mg kg-1,Cr = 50.92 < 90 mg kg-1, Cu = 31.21 < 45 mg kg-1, Fe = 16,007 < 47,200 mg kg-1, Mn = 499.68 < 850 mg kg-1, Ni = 41.17 < 68 mg kg-1, Zn = 50.91 < 95 mg kg-1) in the soils were below the normal background level. The heavy metal contents of the soils in the study area are influenced by various sources (geological structure, agrochemicals used in agricultural activities, and vehicle traffic). The prevailing wind direction did not influence the local distribution of heavy metals in soils in the study area. The health risk assessment model studies showed that the hazard quotient values of less than 1 for adults and children indicate that the noncarcinogenic risks were insignificant. People exposed to heavy metals in the soils of the study area contaminated from various sources for a long time could be at carcinogenic risk. Since Cr and Pb exceed the acceptable risk range in children and Cr exceeds the acceptable risk range in adults, geochemical monitoring of soils should be conducted periodically by authorized institutions in the study area.

Human health ambient water quality criteria and risk assessment of pentachlorophenol in Poyang Lake Basin, China.

Pentachlorophenol (PCP) has been widely used as an insecticide for killing oncomelania (the intermediate host of schistosome) in China and leads to severe environmental contamination. Poyang Lake, as the largest freshwater lake and bird habitat in China, was once a schistosomiasis epidemic area. In this study, the concentrations of PCP in water and aquatic products from Poyang Lake were determined and analyzed, and then the human health ambient water quality criteria (AWQC) was derived based on native parameters of Poyang Lake basin. Finally, a comprehensive analysis of the health risks of drinking water and different types of aquatic products consumption was carried out. The results showed that PCP concentrations were ranged from 0.01 to 0.43 µg/L in surface water and 3.90 to 85.95 µg/kg in aquatic products. Due to the carcinogenicity of PCP, the human health AWQC for PCP are 0.02 µg/L for consumption of water and organisms and 0.03 µg/L for consumption of organisms only. Deterministic and probabilistic risk analysis indicated that the non-carcinogenic risk of PCP were acceptable in Poyang Lake, while the carcinogenic risk cannot be ignored. The health risks of PCP caused by aquatic products consumption were higher than that by drinking water. The percentages of acceptable risk for the population in Poyang Lake Basin were 99.95% at acceptable level of 10-4. Based on the sensitivity analysis, the impact of PCP concentrations on health risk values ranged from 53 to 82%. The study provided valuable information for regional water quality criteria development and water quality assessment.

Assessment of heavy metal contamination in street dust: concentrations, bioaccessibility, and human health risks in coal mine and thermal power plant complex.

Coal mining has also been associated with adverse environmental and health impacts including cancer and respiratory disorders, with the presence of thermal power plants exacerbating the problem of heavy metal pollution. Minimal studies have been conducted on the environmental impacts, health risks, and bioaccessibility of heavy metals in coal mine areas. Consequently, samples of street dust were collected from different locations in the Singrauli mine complex and analysed. Heavy metals (Cu, Ni, Zn, Cr, Co, As, and Mo) were found to be higher than the background concentration, with the maximum concentration was found in areas close to the Thermal Power Plants, like Near Vindyachal TPP, Near Shakti Nagar TPP, and Anpara. The highest geo-accumulation index value was found for Co, Mo, Zn, and As, indicating moderate to strong pollution levels. Health risk assessment (for both adults and children) revealed that Cr and Fe posed significantly higher Hazard Quotient and Hazard Index (HI) values, indicating significant non-carcinogenic threats. Moreover, Carcinogenic Risk (CR) values for Cd, Cr, and Ni indicated a risk of carcinogenicity to the public exposed to road dust. The study also examined the bioaccessibility of the metals, which showed that the gastric phase accumulated a higher percentage of Ni (42.52%), Pb (34.79%), Co (22.22%), As (20%) and Cu (15%) than the intestinal phase. Strong positive correlation was observed between metal concentration (Cu, Pb, Cr, Fe, Zn, and Mn), HI, and CR of adult and child, while bioaccessibility of intestinal phase was positively correlated with gastric phase of metals (Cu, Ni, Co, As, and Mn).