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1.
Am J Otolaryngol ; 45(2): 104128, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38039913

RESUMO

PURPOSE: Laryngeal surgeries using a flexible nasopharyngoscope equipped with an operative channel has gained popularity, with gradual increase in the variety of interventional office-based procedures, under local anesthesia. The purpose of this study is to analyze the tolerance of such procedures. MATERIALS AND METHODS: Retrospective cohort study. 337 cases were performed during 2 years. We collected the following data: type of pathology, type of procedure and modalities of anesthesia, adverse events. RESULTS: 19 % of the visits were for the purpose of Biopsy, 65 % for an injection, and Trublue Laser was utilized in 12 % of the procedures. Regarding the pathologies, 27 % were vocal fold paralysis, 18 % leukoplakia or another suspicious lesion, 15 % recurrent respiratory papillomatosis, 13 % neuromuscular disorder, 9 % vocal fold scarring, 7 % vocal cord atrophy and 6 % had an inflammatory presentation. Side effects were documented in 26 visits (7.7 %) and were minor in almost all the encounters: they included strong reflexive cough, deep throat pain, discomfort, gag reflex, anxiety, vagal discomfort, malaise, hypersalivation, nose pain, labile hypertension. More severe side effects were very rare and included septal wound and epistaxis, erythematous rash, dyspnea, and transient dysarthria. 13 procedures were either aborted, or canceled at initial steps, due to inability of the patient to tolerate the procedure and were rescheduled for general anesthesia. 97 % of the cases were released home after 1 h of surveillance. CONCLUSION: Office-based flexible interventional laryngoscopy under local anesthesia is a safe and well-tolerated procedure, with abundance of various interventions feasible on ambulatory, office-based setup.


Assuntos
Doenças da Laringe , Laringe , Humanos , Estudos Retrospectivos , Resultado do Tratamento , Laringe/cirurgia , Doenças da Laringe/tratamento farmacológico , Prega Vocal , Laringoscopia/efeitos adversos , Procedimentos Cirúrgicos Ambulatórios/efeitos adversos , Dor
2.
Clin Otolaryngol ; 49(6): 822-826, 2024 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-39135379

RESUMO

OBJECTIVES: Vocal process granuloma (VPG) is a chronic condition resulting from a mucoperichondrial injury of vocal process. Initial conservative treatment typically involves vocal hygiene education and antireflux medication. Treatment challenges arise with refractory cases. Outcomes of second-line treatments such as surgical excision and botulinum toxin injections remain inconsistent. Thus, we propose this study to investigate the effectiveness of intralesional steroid injections for refractory VPG. METHODS: We conducted a retrospective review of 23 patients with VPG who showed no improvement after 3 months of proton pump inhibitors. These patients underwent one to three courses of monthly in-office intralesional steroid injections as a second-line therapy. Treatment outcomes were evaluated by measuring the size of the VPG relative to the length of the vocal folds before and after the final injection procedure. RESULTS: Results showed a significant reduction in VPG size from baseline of 27.74 ± 15.06 to 5.48 ± 8.95 (p < .001). 15 out of 23 patients were responsive (size reduction ≥ 75%) to intralesional steroid injection. Alcohol consumption and longer symptom duration were associated with a poor response (size reduction <75%), whereas prior intubation was associated with better response. CONCLUSIONS: For refractory VPG not responding to conservative treatment, intralesional steroid injection appears to be a promising alternative option without significant adverse effects.


Assuntos
Glucocorticoides , Granuloma Laríngeo , Injeções Intralesionais , Prega Vocal , Humanos , Estudos Retrospectivos , Masculino , Feminino , Pessoa de Meia-Idade , Resultado do Tratamento , Adulto , Prega Vocal/lesões , Granuloma Laríngeo/tratamento farmacológico , Glucocorticoides/administração & dosagem , Idoso , Doenças da Laringe/tratamento farmacológico
3.
Can Vet J ; 65(7): 667-674, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38952752

RESUMO

A 21-year-old retired polo Argentinian thoroughbred horse from a teaching herd was presented for a routine bronchoalveolar lavage demonstration, during which an incidental finding of a granulomatous mass on the dorsal aspect of the epiglottis was made. Rhinosporidium seeberi was suspected from a histological section obtained from an initial biopsy, and the mass was removed via laser surgery for cytology and PCR. Sequencing of the PCR amplicons confirmed the diagnosis of R. seeberi. A treatment protocol of nebulized voriconazole for 10 d postoperatively was used. Long-term follow-up required 2 more laser surgeries plus oral fluconazole to resolve the remaining fungal spores. However, 2.5 y later, there was no evidence of remaining fungal spores. Key clinical message: Horses from endemic regions can potentially be exposed to R. seeberi. Based on its travel history, this horse may have contracted the infection in South America, California, or Alberta. Treatments administered, including diode laser resection, voriconazole antifungal nebulization, and oral fluconazole administration, were successful but required repeated interventions.


Suivi à long terme du Rhinosporidium seeberi laryngé diagnostiqué par PCR et traité par ablation au laser et nébulisation au voriconazole chez un cheval de polo thoroughbred pur-sang à la retraiteUn cheval thoroughbred argentin de polo retraité de 21 ans, issu d'un troupeau d'enseignement, a été présenté pour une démonstration de lavage broncho-alvéolaire de routine, au cours de laquelle une découverte fortuite d'une masse granulomateuse sur la face dorsale de l'épiglotte a été faite. Rhinosporidium seeberi a été suspecté à partir d'une coupe histologique obtenue à partir d'une biopsie initiale, et la masse a été retirée par chirurgie au laser pour cytologie et PCR. Le séquençage des amplicons PCR a confirmé le diagnostic de R. seeberi. Un protocole de traitement au voriconazole nébulisé pendant 10 jours après l'opération a été utilisé. Le suivi à long terme a nécessité 2 autres interventions chirurgicales au laser et du fluconazole oral pour éliminer les spores fongiques restantes. Cependant, 2,5 ans plus tard, il n'y avait aucune trace de spores fongiques restantes.Message clinique clé:Les chevaux des régions endémiques peuvent potentiellement être exposés à R. seeberi. D'après ses antécédents de voyage, ce cheval pourrait avoir contracté l'infection en Amérique du Sud, en Californie ou en Alberta. Les traitements administrés, notamment la résection au laser à diode, la nébulisation antifongique au voriconazole et l'administration orale de fluconazole, ont été efficaces mais ont nécessité des interventions répétées.(Traduit par Dr Serge Messier).


Assuntos
Antifúngicos , Doenças dos Cavalos , Nebulizadores e Vaporizadores , Rinosporidiose , Voriconazol , Animais , Cavalos , Doenças dos Cavalos/tratamento farmacológico , Doenças dos Cavalos/cirurgia , Doenças dos Cavalos/diagnóstico , Voriconazol/uso terapêutico , Voriconazol/administração & dosagem , Antifúngicos/uso terapêutico , Antifúngicos/administração & dosagem , Masculino , Rinosporidiose/veterinária , Rinosporidiose/tratamento farmacológico , Rinosporidiose/cirurgia , Rinosporidiose/diagnóstico , Nebulizadores e Vaporizadores/veterinária , Terapia a Laser/veterinária , Reação em Cadeia da Polimerase/veterinária , Doenças da Laringe/veterinária , Doenças da Laringe/cirurgia , Doenças da Laringe/tratamento farmacológico
4.
Rheumatol Int ; 41(6): 1161-1167, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33834281

RESUMO

BACKGROUND: Immunoglobulin G4-related disease (IgG4-RD) is a recently recognized fibro-inflammatory pathology that has been reported to affect principally the retroperitoneum, hepatobiliary system, salivary glands, orbital structures or lymph nodes. However, IgG4-RD with laryngeal involvement is a very rare entity. Our aims were to describe a case of subglottic stenosis as first and only manifestation of IgG4-RD and review the literature. A patient with IgG4-RD affecting the larynx that presented as subglottic stenosis is described. A MEDLINE database search of IgG4-RD cases with laryngopharyngeal manifestations was also conducted. A 30-year-old Caucasian woman was referred to a tertiary care hospital for dyspnea on exertion, which had been increasing for the last 4 months. Medical and surgical procedures revealed a subglottic stenosis, with a histological finding of IgG4 positive plasma cell infiltration. There was no evidence of other organ involvement. She was successfully treated with oral glucocorticoids and rituximab infusions. Glucocorticoids were rapidly tapered and the rituximab regimen was optimized, with no evidence of relapses. In the literature review, we found a total of 12 reported cases with laryngopharyngeal involvement, two of them with subglottic stenosis. IgG4-RD of the larynx is rare but should be considered after excluding more common disorders.


Assuntos
Doença Relacionada a Imunoglobulina G4/diagnóstico , Doenças da Laringe/diagnóstico , Adulto , Idoso , Constrição Patológica/etiologia , Feminino , Humanos , Doença Relacionada a Imunoglobulina G4/tratamento farmacológico , Doença Relacionada a Imunoglobulina G4/patologia , Fatores Imunológicos/administração & dosagem , Doenças da Laringe/tratamento farmacológico , Doenças da Laringe/patologia , Masculino , Pessoa de Meia-Idade , Rituximab/administração & dosagem
5.
Clin Otolaryngol ; 46(5): 935-940, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34051056

RESUMO

OBJECTIVES: Sarcoidosis is a multisystemic inflammatory disease with extrathoracic manifestations, most commonly affecting the young and middle-aged, female and Black populations. Diagnosis usually requires evidence of non-caseating granulomata and, when treated, prognosis is usually favourable. We aim to establish the incidence, clinical features and optimal treatment of ENT manifestations of this disease. DESIGN: We performed a PubMed literature review to determine the evidence base supporting this. RESULTS: ENT manifestations are present in 5%-15% of patients with sarcoidosis, often as a presenting feature, and require vigilance for swift recognition and coordinated additional treatment specific to the organ. Laryngeal sarcoidosis presents with difficulty in breathing, dysphonia and cough, and may be treated by speech and language therapy (SLT) or intralesional injection, dilatation or tissue reduction. Nasal disease presents with crusting, rhinitis, nasal obstruction and anosmia, usually without sinus involvement. It is treated by topical nasal or intralesional treatments but may also require endoscopic sinus surgery, laser treatment or even nasal reconstruction. Otological disease is uncommon but includes audiovestibular symptoms, both sensorineural and conductive hearing loss, and skin lesions. CONCLUSIONS: The consequences of ENT manifestations of sarcoidosis can be uncomfortable, disabling and even life-threatening. Effective management strategies require good diagnostic skills and use of specific therapies combined with established treatments such as corticosteroids. Comparisons of treatment outcomes are needed to establish best practice in this area.


Assuntos
Otopatias/patologia , Doenças da Laringe/patologia , Doenças Nasais/patologia , Sarcoidose/patologia , Diagnóstico Diferencial , Otopatias/diagnóstico , Otopatias/tratamento farmacológico , Humanos , Doenças da Laringe/diagnóstico , Doenças da Laringe/tratamento farmacológico , Doenças Nasais/diagnóstico , Doenças Nasais/tratamento farmacológico , Sarcoidose/diagnóstico , Sarcoidose/tratamento farmacológico
6.
Eur Arch Otorhinolaryngol ; 276(5): 1413-1422, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30859293

RESUMO

PURPOSE: To evaluate the outcome of bilateral trial vocal fold injection (VFI) with hyaluronic acid in patients with vocal fold atrophy ± sulcus and to assess the predictive value of trial VFI on the outcome of durable medialization procedure. METHODS: Voice data collected according to a standardized protocol before and one month after trial VFI of 68 patients with vocal fold atrophy (30) and atrophy with sulcus (38) were analyzed. Voice Handicap Index (VHI)-30 was compared to the outcome of a durable medialization at 3 and 12 months. RESULTS: The overall VHI-30 improvement was 16.8 points (from 49.9 to 33.1), which was statistically significant and clinically relevant. 57.8% of the patients experienced enough subjective benefit after trial VFI to undergo durable medialization. Of the patients that experienced subjective benefit 62% had a clinically relevant improvement in VHI-30. There was no relevant change in other parameters and no difference between ± sulcus. After durable medialization 90-94% of the patients had VHI-30 scores similar to or better than post-trial VFI. CONCLUSION: The majority of patients experience subjective improvement after bilateral trial VFI indicating that medialization is a valid treatment option for patients with vocal fold atrophy ± sulcus. The VHI-30 only partially overlaps with patients' subjective evaluation and does not predict which patients will experience subjective improvement. It is, however, predictive for VHI-30 outcome after durable medialization. The aerodynamic and acoustic parameters showed no relevant change. Further identification of voice assessment parameters accurately reflecting the subjective experience of these patients is warranted.


Assuntos
Ácido Hialurônico/uso terapêutico , Doenças da Laringe/tratamento farmacológico , Viscossuplementos/uso terapêutico , Prega Vocal/patologia , Adulto , Idoso , Atrofia , Feminino , Seguimentos , Humanos , Injeções , Doenças da Laringe/patologia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do Tratamento , Voz
7.
Folia Phoniatr Logop ; 70(1): 1-7, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29847817

RESUMO

OBJECTIVE: Bamboo nodes are vocal fold lesions, mostly associated with autoimmune diseases. PATIENTS AND METHODS: This is a retrospective clinical study including 10 patients with bamboo nodes. Data were collected regarding associated autoimmune disorder and type of treatment. A systematic review of the literature was conducted. RESULTS: All patients were women, with hoarseness as the most frequent symptom. There was in most cases an associated autoimmune disease: 3 patients with systemic lupus erythematosus; 3 with rheumatoid arthritis; 1 with Sjögren syndrome; 1 with Hashimoto disease; and 1 with mixed connective tissue disease. Four patients were treated with speech therapy, 3 with oral steroids, 1 with speech therapy and oral steroids combined, 1 with oral steroids and laryngeal steroid injections, and 1 had oral steroids, surgery, and speech therapy. Speech therapy was the first-line treatment. CONCLUSION: Bamboo nodes should be looked for in every patient with a diagnosis of autoimmune disease complaining of dysphonia.


Assuntos
Doenças Autoimunes/complicações , Doenças do Tecido Conjuntivo/complicações , Disfonia/etiologia , Rouquidão/etiologia , Doenças da Laringe/patologia , Prega Vocal/patologia , Adolescente , Corticosteroides/uso terapêutico , Adulto , Idoso , Disfonia/tratamento farmacológico , Disfonia/terapia , Feminino , Rouquidão/tratamento farmacológico , Rouquidão/terapia , Humanos , Doenças da Laringe/tratamento farmacológico , Doenças da Laringe/imunologia , Doenças da Laringe/cirurgia , Pessoa de Meia-Idade , Estudos Retrospectivos , Fonoterapia , Qualidade da Voz , Adulto Jovem
8.
Am J Otolaryngol ; 38(5): 593-597, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28655420

RESUMO

OBJECTIVES: Vocal process granulomas have a high tendency for persistence despite many treatment alternatives. Anti-reflux medications or botulinum toxin A injections are the main current therapies. There are no studies that compare the effects on vocal process granuloma of proton pump inhibitors plus prokinetic agents with botulinum toxin A injections. STUDY DESIGN: Prospective cohort study. METHODS: Adult patients reporting to our outpatient department complaining of trachyphonia and/or abnormal pharyngeal sensations who were found to have contact granulomas. Patients were divided into two groups according to the treatment: esomeprazole with mosapride citrate (n=26) or botulinum toxin A injection (n=20). The reflux symptom index and reflux finding score determined by electronic fibrolaryngoscopy were utilized to assess efficacy. RESULTS: Forty-six patients were recruited (43 male; 3 female). The mean age (range) was 48.3years (38-69) and the body mass index was 23.51kg/m2 (19.13-27.89). Laryngopharyngeal reflux disease diagnosed by RSI or RFS was found in 18 and 27 patients, respectively, and 18 diagnosed without laryngopharyneal reflux disease. Twenty patients (95%) were cured in the esomeprazole with mosapride citrate group and nine (45%) in the botulinum toxin A group. Eleven (55%) patients had recurrence after botulinum toxin A injection, with an average interval of 3.1months (range 1-6). The recorded symptoms after therapy resolved within 6months with a statistically significant improvement in the esomeprazole with mosapride citrate group. CONCLUSIONS: Combined proton pump inhibitor plus prokinetic drug therapy plays a significant role in the treatment of vocal process granulomas or after surgery.


Assuntos
Benzamidas/uso terapêutico , Toxinas Botulínicas Tipo A/uso terapêutico , Esomeprazol/uso terapêutico , Granuloma/tratamento farmacológico , Doenças da Laringe/tratamento farmacológico , Morfolinas/uso terapêutico , Inibidores da Bomba de Prótons/uso terapêutico , Adulto , Idoso , Estudos de Coortes , Quimioterapia Combinada , Feminino , Fármacos Gastrointestinais/uso terapêutico , Humanos , Masculino , Pessoa de Meia-Idade , Fármacos Neuromusculares/uso terapêutico , Resultado do Tratamento , Prega Vocal
9.
Eur Arch Otorhinolaryngol ; 274(2): 909-917, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-27600559

RESUMO

Data, regarding the use of botulinum toxin (BT-A) in laryngeal dyspnea, are scarce, coming from some cases reports in the literature, including Vocal fold paralysis, laryngeal dystonia, vocal cord dysfunction also called paradoxical motion of the vocal fold (PMVF), and post-neuroleptic laryngeal dyskinesia. There is no consensus regarding the muscles and the doses to inject. The aim of this study is to present a retrospective review of patients treated in our ENT Department by BT-A injection in this indication. This study is a retrospective study describing patients who underwent an injection of botulinum toxin for laryngeal dyspnea in the ENT Department from 2005 to 2015 years. The inclusion criteria were a dyspnea associated with a laryngeal dysfunction, confirmed by flexible fiberoptic nasopharyngolaryngoscopy. Information concerning the causes of the dyspnea, the botulinum toxin BT-A injections procedure, post-injection follow-up, and respiratory outcome were collected for all patients included. In the group of 13 patients included, the main cause identified as principal factor linked with the short breath was: a bilateral VF paralysis (Patel et al., Otolaryngol Head Neck Surg 130:686-689, 7), laryngeal dystonia (Balkissoon and Kenn, Semin Respir Crit Care Med 33:595-605, 2), Anxiety syndrome associated with unilateral vocal fold paralysis or asthma (Marcinow et al., Laryngoscope 124:1425-1430, 3), and an isolated asthma (Zwirner et al., Eur Arch Otorhinolaryngol 254:242-245, 1). Nine out of the thirteen patients were improved by the injections. A BT-A-induced stable benefit for four patients led them to stop the injections in the follow-up. Good outcome was observed in five other patients (main cause: bilateral VP paralysis), allowing a progressive lengthening of the delay between BT-A injections. Four patients did not report a positive risk/benefit ratio after BT-A injections; two of them (with bilateral VF paralysis), because of respiratory side effects and lack of benefit without the side effects for the two others. This failure of effect was not related with BT-A doses injected. This study provides support for using BT-A injections as a symptomatic treatment of periodic laryngeal dyspnea, regardless of the etiologic context. From our data, we suggest that a small starting dose (of around 4 U BT-A Botox®) could be enough for a first injection to obtain a good benefit. The target muscle should be determined by the EMG analysis.


Assuntos
Toxinas Botulínicas Tipo A/uso terapêutico , Toxinas Botulínicas/uso terapêutico , Dispneia/tratamento farmacológico , Dispneia/etiologia , Doenças da Laringe/tratamento farmacológico , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Injeções , Doenças da Laringe/complicações , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
10.
Fortschr Neurol Psychiatr ; 85(8): 450-462, 2017 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-28841743

RESUMO

The treatment of laryngeal dystonias with botulinum toxin is successful. Every patient suffering from a laryngeal dystonia should be assured of high quality therapeutic intervention. Therefore it is important to establish general standards by experts in this field. In this connection, we want to focus here on different relevant aspects of laryngeal dystonias. This includes new aspects in etiology, anatomical landmarks for the injection, standards in diagnostics and therapy and finally open issues needing discussion.


Assuntos
Antidiscinéticos/uso terapêutico , Toxinas Botulínicas/uso terapêutico , Distonia/tratamento farmacológico , Distonia/patologia , Doenças da Laringe/tratamento farmacológico , Doenças da Laringe/patologia , Laringe/patologia , Toxinas Botulínicas/efeitos adversos , Distonia/diagnóstico , Humanos , Injeções Intramusculares
12.
J Emerg Med ; 50(4): 567-80.e1, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-26826769

RESUMO

BACKGROUND: Hereditary angioedema (HAE) is a rare disease characterized by C1-esterase inhibitor (C1-INH) deficiency, resulting in periodic attacks of acute edema, which can be life-threatening if they occur in the upper airway. No head-to-head comparisons of different treatment options for acute HAE attacks are available. Because immediate symptom relief is critical for potentially life-threatening laryngeal attacks, it is important to determine the treatment option that provides optimal treatment response. OBJECTIVE: Review and compare data from clinical studies that evaluated the efficacy and safety of treatments for laryngeal HAE attacks. METHODS: We conducted an indirect comparison of clinical outcomes from prospective studies for treatment of 881 acute laryngeal attacks with plasma-derived C1-INH concentrate (pdC1-INH) at fixed doses (500 or 1000 U) or a body weight-adjusted dose (20 U/kg), recombinant C1-INH concentrate at a fixed dose (2100 U), or a body weight-adjusted dose (50 U/kg), icatibant (30 mg), or ecallantide (30 mg). Comparisons included time to onset of symptom relief and need for re-dosing or emergency procedures. RESULTS: The median time to onset of symptom relief ranged between 15 min and approximately 2 h, and was shortest with body weight-adjusted doses of pdC1-INH. The proportion of laryngeal attacks with re-dosing ranged between 0% and 72%. No re-dosing was needed after treatment with a single body weight-adjusted dose of pdC1-INH (48 attacks). CONCLUSIONS: Available data suggest that among different HAE treatments, body weight-adjusted pdC1-INH (20 U/kg) provides the most reliable treatment response for treatment of laryngeal HAE attacks.


Assuntos
Angioedemas Hereditários/tratamento farmacológico , Angioedemas Hereditários/enzimologia , Proteína Inibidora do Complemento C1/uso terapêutico , Doenças da Laringe/tratamento farmacológico , Doenças da Laringe/enzimologia , Humanos , Resultado do Tratamento
13.
B-ENT ; 12(4): 333-337, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-29709138

RESUMO

Isolated laryngeal leishmaniasis in an immunocompetent patient: a case report. OBJECTIVE: Isolated laryngeal Leishmaniasis presents neither explicit laryngeal lesions nor specific symptoms. In fact, it may mimic many inflammatory and neoplastic diseases. Considering the low incidence of this atypical localization, laryngeal Leishmaniasis, is rarely contemplated by physicians in differential diagnoses of laryngeal tumour lesions. We present the case of a 62-year-old immunocompetent subject who developed a single Leishmania mucosal lesion on the left vocal cord, simulating a laryngeal cancer. METHODS: A case report and discussion of the clinical case by referring to the literature. RESULTS: Specific therapy with miltefosine led to clinical and endoscopic improvement. We had no relapse after three years of follow-up. CONCLUSIONS: This clinical case highlights the need to consider isolated laryngeal Leishmaniasis in the differential diagnoses of laryngeal tumour lesions, even in immunocompetent subjects who live in endemic zones, in order to ensure an early and correct therapeutic approach.


Assuntos
Doenças da Laringe/parasitologia , Leishmaniose , Humanos , Imunocompetência , Doenças da Laringe/diagnóstico , Doenças da Laringe/tratamento farmacológico , Leishmaniose/diagnóstico , Leishmaniose/tratamento farmacológico , Masculino , Pessoa de Meia-Idade
14.
Mov Disord ; 29(6): 729-35, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-24753288

RESUMO

Laryngeal dystonia is a movement disorder of the muscles within the larynx, which most commonly manifests as spasmodic dysphonia (SD). Rarer reported manifestations include dystonic respiratory stridor and dyscoordinate breathing. Laryngeal dystonia has been treated successfully with botulinum neurotoxin (BTX) injections since 1984. We reviewed prospectively collected data in a consecutive series of 193 patients with laryngeal dystonia who were seen at St. Vincent's Hospital between 1991 and 2011. Patient data were analyzed in Excel, R, and Prism. Laryngeal dystonia manifested as SD (92.7%), stridor (11.9%), dystonic cough (6.2%), dyscoordinate breathing (4.1%), paroxysmal hiccups (1.6%), and paroxysmal sneezing (1.6%). There were more women (68.4%) than men (31.6%), and the average age at onset was 47 years. A positive family history of dystonia was present in 16.1% of patients. A higher incidence of extra-laryngeal dystonia (ie, torticollis and blepharospasm) and concurrent manifestations of laryngeal dystonia were present in patients with dystonic cough, dyscoordinate breathing, paroxysmal sneezing, and hiccups than in other patients (P = 0.003 and P < 0.0001, respectively). The average starting dose of BTX decreased from 2.3 to 0.5 units between 1991 and 2011. The median treatment rating was excellent across all subgroups. Patients with adductor SD, stridor, extra-laryngeal dystonia and male patients had relatively better treatment outcomes. Technical failures were rare (1.1%). Dysphonia secondary to vocal cord paresis followed 38.7% of treatments. Laryngeal dystonia manifests predominantly as SD, but other manifestations include stridor, dyscoordinate breathing, paroxysmal cough, hiccups, and sneezing. BTX injections are very effective across all subgroups. Severe adverse events are rare.


Assuntos
Tosse/etiologia , Distonia/complicações , Doenças da Laringe/complicações , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Toxinas Botulínicas/uso terapêutico , Tosse/tratamento farmacológico , Distonia/classificação , Distonia/tratamento farmacológico , Feminino , Humanos , Doenças da Laringe/tratamento farmacológico , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Neurotoxinas/uso terapêutico , Observação , Estudos Retrospectivos , Índice de Gravidade de Doença , Adulto Jovem
15.
Rev Med Suisse ; 10(444): 1811-2, 1814-5, 2014 Oct 01.
Artigo em Francês | MEDLINE | ID: mdl-25417337

RESUMO

Bamboo nodes are sub mucous lesions localized in the vocal folds. Their aspect reminds of the nodes in a bamboo, which gives them their name. The diagnosis is made by laryngoscopy. Those lesions are always associated with autoimmune diseases: systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome, Hashimoto, progressive systemic sclerosis. The treatment is not clearly described in literature. It is recommended to start with systemic steroids and speech therapy. If the regression of laryngeal lesions is not suf- ficient, it is advised to complete with local steroid injections. Surgery should be consi- dered as the last treatment. We describe a clinical case of bamboo nodes and make a review of literature.


Assuntos
Doenças Autoimunes/diagnóstico , Doenças da Laringe/diagnóstico , Prega Vocal/patologia , Adolescente , Doenças Autoimunes/complicações , Doenças Autoimunes/tratamento farmacológico , Doenças Autoimunes/patologia , Feminino , Humanos , Doenças da Laringe/tratamento farmacológico , Doenças da Laringe/patologia , Triancinolona/uso terapêutico
16.
Expert Opin Drug Deliv ; 21(4): 573-591, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38588553

RESUMO

INTRODUCTION: Endotracheal intubation is a common procedure to maintain an open airway with risks for traumatic injury. Pathological changes resulting from intubation can cause upper airway complications, including vocal fold scarring, laryngotracheal stenosis, and granulomas and present with symptoms such as dysphonia, dysphagia, and dyspnea. Current intubation-related laryngotracheal injury treatment approaches lack standardized guidelines, relying on individual clinician experience, and surgical and medical interventions have limitations and carry risks. AREAS COVERED: The clinical and preclinical therapeutics for wound healing in the upper airway are described. This review discusses the current developments on local drug delivery systems in the upper airway utilizing particle-based delivery systems, including nanoparticles and microparticles, and bulk-based delivery systems, encompassing hydrogels and polymer-based approaches. EXPERT OPINION: Complex laryngotracheal diseases pose challenges for effective treatment, struggling due to the intricate anatomy, limited access, and recurrence. Symptomatic management often requires invasive surgical procedures or medications that are unable to achieve lasting effects. Recent advances in nanotechnology and biocompatible materials provide potential solutions, enabling precise drug delivery, personalization, and extended treatment efficacy. Combining these technologies could lead to groundbreaking treatments for upper airways diseases, significantly improving patients' quality of life. Research and innovation in this field are crucial for further advancements.


Assuntos
Sistemas de Liberação de Medicamentos , Cicatrização , Humanos , Cicatrização/efeitos dos fármacos , Animais , Intubação Intratraqueal/métodos , Qualidade de Vida , Nanopartículas , Hidrogéis/administração & dosagem , Materiais Biocompatíveis/administração & dosagem , Materiais Biocompatíveis/química , Polímeros/química , Nanotecnologia , Doenças da Laringe/tratamento farmacológico , Traqueia/lesões
17.
BMJ Case Rep ; 17(8)2024 Aug 19.
Artigo em Inglês | MEDLINE | ID: mdl-39159986

RESUMO

A woman in her early 30s presented to her primary care physician's office with hoarseness, joint pain and facial swelling. The objective evaluation revealed elevated inflammatory markers and angiotensin-1-converting enzyme, a chest radiograph with bilateral hilar prominence and a maxillofacial CT scan with diffuse inflammation in the upper airway. Otolaryngology evaluation revealed exophytic lesions diffusely within the nasal cavity, base of tongue, supraglottis, glottis and trachea. A biopsy confirmed the diagnosis of sarcoidosis. She was treated with corticosteroids with improvement in upper and lower airway symptoms. She continued to experience other extrapulmonary manifestations of sarcoidosis requiring alternative immunosuppressant therapy. At 30 months from symptom onset, her disease was noted to be in remission.


Assuntos
Doenças da Laringe , Sarcoidose , Doenças da Traqueia , Humanos , Feminino , Sarcoidose/diagnóstico , Sarcoidose/tratamento farmacológico , Sarcoidose/patologia , Doenças da Laringe/tratamento farmacológico , Doenças da Laringe/diagnóstico , Doenças da Laringe/patologia , Doenças da Laringe/diagnóstico por imagem , Adulto , Doenças da Traqueia/diagnóstico , Doenças da Traqueia/diagnóstico por imagem , Doenças da Traqueia/patologia , Tomografia Computadorizada por Raios X , Traqueia/patologia , Traqueia/diagnóstico por imagem
18.
Ann Otol Rhinol Laryngol ; 122(1): 9-14, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23472310

RESUMO

OBJECTIVES: A number of laryngeal injection techniques have been described for performing vocal fold medialization or delivery of medications, including peroral and percutaneous approaches. Although flexible nasolaryngoscopy-guided injection (FNGI) improves visualization and patient tolerance over rigid endoscopy, the technique requires an assistant to manipulate the laryngoscope. The efficacy and patient tolerance of a novel, single-operator technique for FNGI are evaluated. METHODS: Patients who required laryngeal injection for vocal fold medialization or for administration of cidofovir or steroids were included in this study. Indications included vocal fold paresis or paralysis, sulcus deformities, recurrent respiratory papillomatosis, vocal fold polyps, and laryngeal granulomas. All procedures were performed in the office setting with topical and local anesthesia with the patient awake. The surgeon performed flexible nasolaryngoscopy with the nondominant hand while using the dominant hand to perform transthyrohyoid injection with a 25-gauge needle with proximal and distal bends. RESULTS: Twenty-six patients underwent a total of 42 single-operator FNGI procedures; 19 unilateral and 23 bilateral injections were performed. All but 1 of the procedures were completed with adequate visualization and placement of injectant and good patient tolerance. CONCLUSIONS: Single-operator FNGI via a transthyrohyoid approach is a viable and versatile laryngeal injection technique for a variety of indications. It provides access to the anterior, middle, and posterior parts of the larynx. It eliminates the need for an assistant experienced in nasolaryngoscopy and allows the surgeon to adjust and optimize visualization in a fashion analogous to endoscopic sinus surgery.


Assuntos
Citosina/análogos & derivados , Glucocorticoides/administração & dosagem , Doenças da Laringe/tratamento farmacológico , Laringoscópios , Laringoscopia/métodos , Organofosfonatos/administração & dosagem , Antineoplásicos/administração & dosagem , Cidofovir , Citosina/administração & dosagem , Desenho de Equipamento , Feminino , Seguimentos , Humanos , Injeções/métodos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do Tratamento , Prega Vocal
19.
Am J Otolaryngol ; 34(4): 362-5, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23391346

RESUMO

OBJECTIVE: An epiglottic abscess is considered a life-threatening medical situation that can cause death by obstruction the upper airways. We describe a 58-year-old man who presented to our hospital with sore throat, dysphagia and dysphonia. MATERIALS AND METHODS: A fiberoptic laryngoscope (FOL) demonstrated beefy red edematous epiglottis with edema extending from the base of the tongue to the aryepiglottic folds and arytenoids. CT scan showed multiple air bubbles inside the swollen epiglottis, in keeping with the diagnosis of necrotizing epiglottic abscess. RESULTS: Under local anesthesia we performed puncture of the abscess at the tip of the epiglottis. He was dismissed 5days from his admission to the hospital after an improvement was noticed in his epiglottis. CONCLUSION: Treatment consists of airway management if needed under anesthesia and draining of the abscess. An IV antibiotics plus corticosteroids should be administrated the moment a suspicion of epiglottitis is present.


Assuntos
Abscesso/etiologia , Corticosteroides/uso terapêutico , Antibacterianos/uso terapêutico , Epiglotite/complicações , Doenças da Laringe/etiologia , Abscesso/diagnóstico por imagem , Abscesso/tratamento farmacológico , Doença Aguda , Transtornos de Deglutição/diagnóstico , Transtornos de Deglutição/etiologia , Quimioterapia Combinada , Serviço Hospitalar de Emergência , Epiglotite/diagnóstico por imagem , Epiglotite/tratamento farmacológico , Seguimentos , Humanos , Doenças da Laringe/diagnóstico por imagem , Doenças da Laringe/tratamento farmacológico , Laringoscopia/métodos , Masculino , Pessoa de Meia-Idade , Faringite/diagnóstico , Faringite/etiologia , Medição de Risco , Índice de Gravidade de Doença , Tomografia Computadorizada por Raios X/métodos , Resultado do Tratamento
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