RESUMO
Leukaemia cutis is a relatively rare manifestation in chronic lymphocytic leukaemia, characterized by a diverse morphology of skin lesions. We report two patients who developed zosteriform skin symptoms; however, the histological analysis revealed leukaemia infiltration as the cause of their symptoms. Contrary to previous reports, varicella zoster virus DNA was detectable in the lesions. These findings suggest that varicella zoster virus plays an active role in the development of zosteriform leukaemia cutis.
Assuntos
DNA Viral/isolamento & purificação , Herpesvirus Humano 3 , Leucemia Linfocítica Crônica de Células B/patologia , Infiltração Leucêmica/patologia , Pele/patologia , Idoso , Feminino , Humanos , Infiltração Leucêmica/virologia , Masculino , Pessoa de Meia-Idade , Pele/virologiaAssuntos
Leucemia-Linfoma de Células T do Adulto/patologia , Infiltração Leucêmica/patologia , Pulmão/patologia , Feminino , Humanos , Leucemia-Linfoma de Células T do Adulto/sangue , Leucemia-Linfoma de Células T do Adulto/virologia , Infiltração Leucêmica/sangue , Infiltração Leucêmica/virologia , Pulmão/virologia , Pessoa de Meia-Idade , Remissão EspontâneaRESUMO
We have shown previously that exacerbation of corneal scarring (CS) in HSV-1 glycoprotein K (gK) immunized mice was associated with CD8+ T cells. In this study, we investigated the type and the nature of the immune responses that are involved in the exacerbation of CS in gK-immunized animals. BALB/c mice were vaccinated with baculovirus expressed gK, gD, or mock-immunized. Twenty-one days after the third immunization, mice were ocularly infected with 2 x 10(5) PFU/eye of virulent HSV-1 strain McKrae. Infiltration of the cornea by CD4+, CD8+, CD25+, CD4+CD25+, CD8+CD25+, CD19+, CD40+, CD40L+, CD62L+, CD95+, B7-1+, B7-2+, MHC-I+, and MHC-II+ cells was monitored by immunohistochemistry, qRT-PCR and FACS at various times post-infection (PI). This study demonstrated for the first time that the presence of CD8+CD25+ T cells in the cornea is correlated with exacerbation of CS in the gK-immunized group.