RESUMO
O lipoblastoma é um tumor mesenquimal raro, composto de lipoblastos que continuam sua proliferação após o período pós-natal e que acometem, predominantemente, a população pediátrica. Apresenta prognóstico excelente, apesar do potencial de invasão local e do crescimento rápido. Os autores relatam o caso de uma paciente pediátrica portadora de volumosa lesão em antebraço direito, ocasionando importante comprometimento funcional do membro acometido. Aspectos relevantes no diagnóstico diferencial e manejo são discutidos neste trabalho, visto tratar-se de lesão com potencial risco incapacitante futuro, caso não manejada corretamente.
Lipoblastoma is a rare mesenchymal tumor occurring primarily in pediatric patients and formed by lipoblasts that proliferate after the postnatal period. Despite its potential for local invasion and rapid growth, its prognosis is excellent. In this study, we report the case of a pediatric patient with a ponderous lesion in the right forearm that caused considerable functional impairment of the affected limb. We also discuss the relevant aspects concerning the differential diagnosis and management of the disease, as it has the potential to cause incapacity without proper treatment.
Assuntos
Humanos , Feminino , Lactente , História do Século XXI , Neoplasias de Tecidos Moles , Cirurgia Plástica , Ferimentos e Lesões , Literatura de Revisão como Assunto , Tecido Adiposo , Adipócitos , Estudo de Avaliação , Lipoma , Neoplasias de Tecidos Moles/cirurgia , Neoplasias de Tecidos Moles/patologia , Cirurgia Plástica/métodos , Ferimentos e Lesões/cirurgia , Tecido Adiposo/embriologia , Tecido Adiposo/metabolismo , Adipócitos/fisiologia , Adipócitos/metabolismo , Lipoblastoma , Lipoblastoma/cirurgia , Lipoblastoma/patologia , Lipoma/cirurgia , Lipoma/patologiaRESUMO
There are still uncertainties about the origin of the fatty acids (FA) deposited in the foetus, notably the percentage derived from the maternal circulation. This study describes a method to determine the amount of FA synthesized de novo in the foetus and the amount derived from the maternal circulation. Autopsy samples of subcutaeneous adipose tissue were obtained from 42 black foetuses and newborn infants. Samples of similar tissue were obtained from 50 pregnant women and 13 non-pregnant black women during surgery. FA analysis was done by gas chromatography. The accretion rate of FA in foetal adipose tissue was calculated by linear regression analysis of the FA data obtained from foetal/infant samples from the 22nd to 43rd week of gestation. The rate of foetal FA synthesized de novo in adipose tissue was calculated as the difference between the total foetal FA accretion rate and an estimate of the maternally derived FA. The latter was estimated from the values for accretion rates of saturated FA (SAFA), mono-unsaturated FA (MUFA), and polyunsaturated FA (PUFA) and total FA in foetal tissue, and the SAFA, MUFA and PUFA composition of adipose tissue in women (Table). Results show that of the total FA increment in foetal adipose tissue (22.7mg/g wet wt./week), 86.6 per cent was synthesized de novo by the foetus and the rest (13.2 per cent) was maternally derived (AU)
Assuntos
Humanos , Feminino , Gravidez , Recém-Nascido , Técnicas In Vitro , Desenvolvimento Embrionário e Fetal , Ácidos Graxos/metabolismo , Tecido Adiposo/embriologia , Proteínas Fetais , Troca Materno-FetalRESUMO
Currently the research on adipose tissue has yielded same insights of itïs function. On the embrionary state the differentiation between white adipose tissue and brown adipose tissue and brown adipose tissue signals different functions. The presence of multiple receptors and actions define itïs autocrine, paracline and endocrine roles