Pesquisa | BVS IEC

1.

Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway.

Nie, Qixing; Luo, Xi; Wang, Kai; Ding, Yong; Jia, Shumi; Zhao, Qixiang; Li, Meng; Zhang, Jinxin; Zhuo, Yingying; Lin, Jun; Guo, Chenghao; Zhang, Zhiwei; Liu, Huiying; Zeng, Guangyi; You, Jie; Sun, Lulu; Lu, Hua; Ma, Ming; Jia, Yanxing; Zheng, Ming-Hua; Pang, Yanli; Qiao, Jie; Jiang, Changtao.

Cell ; 187(11): 2717-2734.e33, 2024 May 23.

Artigo em Inglês | MEDLINE | ID: mdl-38653239

2.

OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB.

Ma, Wenhao; Sun, Yuchen; Yan, Ronghui; Zhang, Pinggen; Shen, Shengqi; Lu, Hui; Zhou, Zilong; Jiang, Zetan; Ye, Ling; Mao, Qiankun; Xiong, Nanchi; Jia, Weidong; Sun, Linchong; Gao, Ping; Zhang, Huafeng.

Mol Cell ; 84(3): 538-551.e7, 2024 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-38176415

3.

Evolvability as a function of purifying selection in TEM-1 ß-lactamase.

Stiffler, Michael A; Hekstra, Doeke R; Ranganathan, Rama.

Cell ; 160(5): 882-892, 2015 Feb 26.

Artigo em Inglês | MEDLINE | ID: mdl-25723163

4.

Structure of a B₁₂-dependent radical SAM enzyme in carbapenem biosynthesis.

Knox, Hayley L; Sinner, Erica K; Townsend, Craig A; Boal, Amie K; Booker, Squire J.

Nature ; 602(7896): 343-348, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-35110734

5.

Cefepime-Taniborbactam in Complicated Urinary Tract Infection.

Wagenlehner, Florian M; Gasink, Leanne B; McGovern, Paul C; Moeck, Greg; McLeroth, Patrick; Dorr, MaryBeth; Dane, Aaron; Henkel, Tim.

N Engl J Med ; 390(7): 611-622, 2024 Feb 15.

Artigo em Inglês | MEDLINE | ID: mdl-38354140

6.

Rational design of a new antibiotic class for drug-resistant infections.

Durand-Reville, Thomas F; Miller, Alita A; O'Donnell, John P; Wu, Xiaoyun; Sylvester, Mark A; Guler, Satenig; Iyer, Ramkumar; Shapiro, Adam B; Carter, Nicole M; Velez-Vega, Camilo; Moussa, Samir H; McLeod, Sarah M; Chen, April; Tanudra, Angela M; Zhang, Jing; Comita-Prevoir, Janelle; Romero, Jan A; Huynh, Hoan; Ferguson, Andrew D; Horanyi, Peter S; Mayclin, Stephen J; Heine, Henry S; Drusano, George L; Cummings, Jason E; Slayden, Richard A; Tommasi, Ruben A.

Nature ; 597(7878): 698-702, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-34526714

7.

Network of epistatic interactions in an enzyme active site revealed by large-scale deep mutational scanning.

Judge, Allison; Sankaran, Banumathi; Hu, Liya; Palaniappan, Murugesan; Birgy, André; Prasad, B V Venkataram; Palzkill, Timothy.

Proc Natl Acad Sci U S A ; 121(12): e2313513121, 2024 Mar 19.

Artigo em Inglês | MEDLINE | ID: mdl-38483989

8.

Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.

Huseby, Douglas L; Cao, Sha; Zamaratski, Edouard; Sooriyaarachchi, Sanjeewani; Ahmad, Shabbir; Bergfors, Terese; Krasnova, Laura; Pelss, Juris; Ikaunieks, Martins; Loza, Einars; Katkevics, Martins; Bobileva, Olga; Cirule, Helena; Gukalova, Baiba; Grinberga, Solveiga; Backlund, Maria; Simoff, Ivailo; Leber, Anna T; Berruga-Fernández, Talía; Antonov, Dmitry; Konda, Vivekananda R; Lindström, Stefan; Olanders, Gustav; Brandt, Peter; Baranczewski, Pawel; Vingsbo Lundberg, Carina; Liepinsh, Edgars; Suna, Edgars; Jones, T Alwyn; Mowbray, Sherry L; Hughes, Diarmaid; Karlén, Anders.

Proc Natl Acad Sci U S A ; 121(15): e2317274121, 2024 Apr 09.

Artigo em Inglês | MEDLINE | ID: mdl-38579010

9.

sRNA expression profile of KPC-2-producing carbapenem-resistant Klebsiella pneumoniae: Functional role of sRNA51.

Bai, Yibo; Xie, Chonghong; Zhang, Yue; Zhang, Zhijie; Liu, Jianhua; Cheng, Guixue; Li, Yan; Wang, Di; Cui, Bing; Liu, Yong; Qin, Xiaosong.

PLoS Pathog ; 20(5): e1012187, 2024 May.

Artigo em Inglês | MEDLINE | ID: mdl-38718038

10.

Molecular responses during bacterial filamentation reveal inhibition methods of drug-resistant bacteria.

Zhang, Dongxue; Yin, Fan; Qin, Qin; Qiao, Liang.

Proc Natl Acad Sci U S A ; 120(27): e2301170120, 2023 07 04.

Artigo em Inglês | MEDLINE | ID: mdl-37364094

11.

Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.

Mehrotra, Tanshi; Konar, Dipasri; Pragasam, Agila Kumari; Kumar, Shakti; Jana, Pradipta; Babele, Prabhakar; Paul, Deepjyoti; Purohit, Ayushi; Tanwar, Subhash; Bakshi, Susmita; Das, Santanu; Verma, Jyoti; Talukdar, Daizee; Narendrakumar, Lekshmi; Kothidar, Akanksha; Karmakar, Sonali Porey; Chaudhuri, Susmita; Pal, Sujoy; Jain, Kajal; Srikanth, Chittur V; Sankar, M Jeeva; Atmakuri, Krishnamohan; Agarwal, Ramesh; Gaind, Rajni; Ballal, Mamatha; Kammili, Nagamani; Bhadra, Rupak K; Ramamurthy, Thandavarayan; Nair, G Balakrish; Das, Bhabatosh.

Proc Natl Acad Sci U S A ; 120(33): e2305465120, 2023 08 15.

Artigo em Inglês | MEDLINE | ID: mdl-37549252

12.

Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops.

Sun, Zhizeng; Lin, Hanfeng; Hu, Liya; Neetu, Neetu; Sankaran, Banumathi; Wang, Jin; Prasad, B V Venkataram; Palzkill, Timothy.

J Biol Chem ; 300(1): 105493, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-38000656

13.

The LysR-type transcription factor LsrB regulates beta-lactam resistance in Agrobacterium tumefaciens.

Schmidt, Janka J; Remme, Donata C L E; Eisfeld, Jessica; Brandenburg, Vivian B; Bille, Hannah; Narberhaus, Franz.

Mol Microbiol ; 121(1): 26-39, 2024 01.

Artigo em Inglês | MEDLINE | ID: mdl-37985428

14.

In-cell kinetic stability is an essential trait in metallo-ß-lactamase evolution.

González, Lisandro J; Bahr, Guillermo; González, Mariano M; Bonomo, Robert A; Vila, Alejandro J.

Nat Chem Biol ; 19(9): 1116-1126, 2023 09.

Artigo em Inglês | MEDLINE | ID: mdl-37188957

15.

The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding.

Bennett, Jeremy A; Steward, Lottie R; Rudolph, Johannes; Voss, Adam P; Aydin, Halil.

PLoS Biol ; 20(12): e3001899, 2022 12.

Artigo em Inglês | MEDLINE | ID: mdl-36534696

16.

Ultra-large library docking for discovering new chemotypes.

Lyu, Jiankun; Wang, Sheng; Balius, Trent E; Singh, Isha; Levit, Anat; Moroz, Yurii S; O'Meara, Matthew J; Che, Tao; Algaa, Enkhjargal; Tolmachova, Kateryna; Tolmachev, Andrey A; Shoichet, Brian K; Roth, Bryan L; Irwin, John J.

Nature ; 566(7743): 224-229, 2019 02.

Artigo em Inglês | MEDLINE | ID: mdl-30728502

17.

Global distribution and genomic characteristics of carbapenemase-producing Escherichia coli among humans, 2005-2023.

Li, Yan; Sun, Xinran; Dong, Ning; Wang, Zhiqiang; Li, Ruichao.

Drug Resist Updat ; 72: 101031, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-38071860

18.

Global spread characteristics of CTX-M-type extended-spectrum ß-lactamases: A genomic epidemiology analysis.

Yu, Keyi; Huang, Zhenzhou; Xiao, Yue; Gao, He; Bai, Xuemei; Wang, Duochun.

Drug Resist Updat ; 73: 101036, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38183874

19.

Studies on enmetazobactam clarify mechanisms of widely used ß-lactamase inhibitors.

Lang, Pauline A; Raj, Ritu; Tumber, Anthony; Lohans, Christopher T; Rabe, Patrick; Robinson, Carol V; Brem, Jürgen; Schofield, Christopher J.

Proc Natl Acad Sci U S A ; 119(18): e2117310119, 2022 05 03.

Artigo em Inglês | MEDLINE | ID: mdl-35486701

20.

The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis.

Guthertz, N; van der Kant, R; Martinez, R M; Xu, Y; Trinh, C H; Iorga, B I; Rousseau, F; Schymkowitz, J; Brockwell, D J; Radford, S E.

Proc Natl Acad Sci U S A ; 119(22): e2200468119, 2022 05 31.

Artigo em Inglês | MEDLINE | ID: mdl-35613051

BVS IEC

Instituto Evandro Chagas

Configurar filtros

Sua seleção (0)

Formato de exportação:

Exportar: