Use of erythrocytes in cytotoxicity and toxicity assays of medicinal plant extracts: analysis of their application and bibliometric study / Utilización de eritrocitos en ensayos de citotoxicidad y toxidez de extractos de plantas medicinales: análisis de su aplicación y estudio bibliométrico
Figueirêdo Júnior, Ernani Canuto; Costa, Bruna Palmeira; Freire, Julliana Cariry Palhano; Melo, Waleska Ohana de Sousa; Pessôa, Hilzeth de Luna Freire; Gomes, Daliana Queiroga de Castro; Costa, Edja Maria Melo de Brito; Pereira, Jozinete Vieira.
Bol. latinoam. Caribe plantas med. aromát
; 18(4): 359-377, jul. 2019. tab
Artigo
em Inglês
| LILACS | ID: biblio-1008174
Plant species have been used for therapeutic purposes since ancient times and are still in use today since these products represent a source of raw material for the production of phytotherapeutic formulations. Screening and investigation of plants with pharmacological potential require the evaluation of characteristics related to their action, efficacy and safety in different steps. Among these steps, pre- clinical trials are used to evaluate the properties of the test product in in vitro experiments, such as cytotoxicity assays. Within this context, this study consists of a bibliometric analysis of some in vitro cytotoxicity and toxicity assays in erythrocytes used during bioprospecting of medicinal plants. The results demonstrated the wide application of erythrocytes to evaluate the biological effects of medicinal plant extracts. The methods were found to be valid and effective for the preliminary investigation of the in vitro cytotoxicity and toxicity of plant products.
Biblioteca responsável:
CL1.1
Texto completo
Documentos relacionados