Increased risk of mortality in systemic sclerosis-associated pulmonary hypertension: a systemic review and meta-analysis
Adv Rheumatol
; 62: 10, 2022. tab, graf
Article
em En
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LILACS-Express
| LILACS
| ID: biblio-1374208
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Background:
Pulmonary hypertension (PH) is a frequent complication of systemic sclerosis (SSc) and is currently one of the primary causes of death in patients with this disease. We conducted a systematic review and meta-analysis to assess the association between PH and mortality in patients with SSc to verify trends in mortality in patients with SSc-associated PH.Methods:
We searched the PubMed and Embase databases for published studies on SSc-associated PH from inception to May 2021. All cohort studies in which mortality and/or survival for SSc-associated PH were reported were included in the analysis. The outcome parameters were pooled and analyzed using a random-effects model via generic inverse-variance weighting in conventional and cumulative meta-analysis.Results:
The literature search identified 1161 citations, and the full texts of 54 studies were examined. Sixteen articles, with a total of 7857 patients with SSc and 1140 patients with SSc-associated PH, were included in the metaanalysis. Patients with SSc-associated PH had a higher pooled risk of mortality than patients with SSc without PH (risk ratio = 3.12; 95% confidence interval [2.44, 3.98]).Conclusions:
This meta-analysis revealed a higher mortality in patients with SSc-associated PH. PH was a significant predictor of death in patients with SSc. Thus, early diagnosis and treatment of PH are important in patients with SSc.
Texto completo:
1
Base de dados:
LILACS
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
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Systematic_reviews
Idioma:
En
Revista:
Adv Rheumatol
Assunto da revista:
Artrite
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Reumatologia
Ano de publicação:
2022
Tipo de documento:
Article
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Project document
País de afiliação:
China