Association of Tumor Necrosis Factor-α (-G308A) Polymorphism with risk of Upper Gastrointestinal Bleeding from Schistosomiasis in Pernambuco
Rev. Soc. Bras. Med. Trop
; 56: e0654, 2023. tab
Article
em En
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LILACS-Express
| LILACS
| ID: biblio-1422880
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT Background:
We evaluated the association between polymorphisms in the tumor necrosis factor alpha (TNF-α) (-G308A) gene and upper gastrointestinal bleeding (UGIB) in schistosomiasis.Methods:
This was a transverse study involving 294 Brazilian patients infected with Schistosoma mansoni.Results:
The homozygous A/A genotype in TNF-α (-G308A) showed a risk association (prevalence ratio = 1.90, p = 0.008) with UGIB. There was no statistically significant difference in serum TNF-α levels between the clinical groups.Conclusions:
The polymorphic TNF-α (-G308A) can be a risk factor for UGIB, in addition to being a potentially predictive factor for the severity of UGIB in schistosomiasis.
Texto completo:
1
Base de dados:
LILACS
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
MEDICINA TROPICAL
Ano de publicação:
2023
Tipo de documento:
Article
/
Project document
País de afiliação:
Brasil