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Instituto Evandro Chagas

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Bioactive dicaffeoylquinic acid derivatives from the root extract of Calea urticifolia

Mijangos-Ramos, Ivan Felipe; Zapata-Estrella, Hiatzy E.; Ruiz-Vargas, Javier A.; Escalante-Erosa, Fabiola; Gómez-Ojeda, Noemi; García-Sosa, Karlina; Cechinel-Filho, Valdir; Meira-Quintão, Nara L.; Peña-Rodríguez, Luis M..
Rev. bras. farmacogn ; 28(3): 339-343, May-June 2018. tab, graf
Artigo em Inglês | LILACS | ID: biblio-958866
ABSTRACT Calea urticifolia (Mill.) DC., Asteraceae, is a native plant of the Yucatan Peninsula used in traditional medicine to treat inflammation and pain. The bioassay-guided purification of the ethanol root extract allowed the isolation of the main bioactive metabolites, which were identified as an inseparable mixture of thymol (1) and 3-methyl-4-isopropylphenol (2), together with 3,4-O-dicaffeoylquinic acid methyl ester (3), 3,4-O-dicaffeoyl-epi-quinic acid methyl ester (4), 3,5-O-dicaffeoyl-epi-quinic acid methyl ester (5) and 3,5-O-dicaffeoylquinic acid (6). The results showed that the analgesic activity detected in the root extract of C. urticifolia could be attributed mainly to the mixture of 1 and 2 and to the novel 3,4-O-dicaffeoyl-epi-quinic acid methyl ester (4). Alternatively, the similarity on the antiinflammatory and antioxidant activities of the dicaffeoylquinic acid derivatives 3-5 suggests that the former might be related to their ability as radical scavengers.
Biblioteca responsável: BR1.1