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Instituto Evandro Chagas

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Influence of tramadol on functional recovery of acute spinal cord injury in rats

Chaves, Rosa Helena de Figueiredo; Souza, Celice Cordeiro de; Furlaneto, Ismari Perini; Teixeira, Renan Kleber Costa; Oliveira, Carolina Pinheiro de; Rodrigues, Emanuelle de Matos; Santos, Daniel Arthur Santos dos; Silva, Renata Cunha; Penha, Nelson Elias Abrahão da; Lima, Ana Rita de.
Acta cir. bras ; 33(12): 1087-1094, Dec. 2018. tab, graf
Artigo em Inglês | LILACS | ID: biblio-973483
Abstract

Purpose:

To evaluate the influence tramadol on functional recovery of acute spinal cord injury in rats.

Methods:

Ten rats were divided into two groups (n = 5). All animals were submitted by a laminectomy and spinal cord injury at eighth thoracic vertebra. In control group, the rats didn't receive any analgesic. In tramadol group, the rats received tramadol 4mg/Kg at 12/12h until 5 days by subcutaneous. Animals were following by fourteen days. Was evaluated the Basso, Beattie, Bresnahan scale (locomotor evaluation) and Rat Grimace Scale (pain evaluation) at four periods.

Results:

There no difference between the groups in locomotor evaluation in all periods evaluated (p>0.05) and in both groups there was a partial recover of function. The tramadol group show a lower pain levels at the first, third and seventh postoperatively days when comparing to the control group.

Conclusion:

The tramadol as an analgesic agent don't influence on functional recovery of acute spinal cord injury in rats
Biblioteca responsável: BR1.1