Recorrência de Plasmodium falciparum após tratamento com quinina e doxiciclina na bacia amazônica/Recurrence of Plasmodium falciparum after treatment with quinine and doxycycline in the Amazon basin
Six of 40 patientswho met the criteria for inclusion in the study showed recurrence of parasitaemia within 28 days after the commencement of treatment. A group of six patients with adequate parasitological response was formed to avoid bias when the variables were compared. Parasitaemia at admission was similar in both groups. Plasmaquinine concentrations were similar in both groups on days 1, 2 and 3 and ranged from 1.07 to 4.35 lg/ml in cured patients and from 1.1 to 3.2 lg/ml in patients with parasiterecurrence. Concentrations of doxycycline were similar in both groups on day 3. The parasite clearance rate constant was 0.131 mais ou menos 0.16h in the cured patients and 0.117 mais ou menos 0.02h in those showing recurrence. The slope half-life in the cured patients was 4.8h and 5.4h in recurrence cases. The hillslope of the cured group (14.24) increased sharply compared to the recurrence group (4.13).