Study of the antibacterial activity of thymol and carvacrol monoterpenes against strains of Escherichia coli producing extended-spectrum ß-lactamases/Estudo da atividade antibacteriana dos monoterpenos timol e carvacrol contra cepas de Escherichia coli produtoras de ß-lactamases de amplo espectro
Artigo
em Português
| Instituto Evandro Chagas (SOPHIA) | ID: iec-16168
OBJETIVOS:
Estudar a atividade antimicrobiana dos fitoconstituintes timol e carvacrol contras cepas de Escherichia coli produtoras de B-lactamases de amplo espectro (ESBL) e determinar a concentração inibitória mínima (CIM) do timol e do carvacrol.
A CIM do carvacrol apresentou concentrações de 64 µg/mL para a cepa 65 e 128 µg/mL para as cepas C-18, C-20, C-21, C-24, C-25 e 24. Já frente à ação do timol, a CIM foi determinada como 1.024 µg/mL para a cepa C-25; 512 µg/mL para as cepas C-18, C-21, 24 e 65; 256 µg/mL para a cepa C-24; e 128 µg/mL para a cepa C-20.
CONCLUSÃO:
Por meio dos experimentos, pôde-se afirmar que os fitoconstituintes carvacrol e timol exercem atividade bacteriostática sobre as cepas de E. coli
The experiments were carried out at the MicrobiologyLaboratory (J11) at the Education and Health Center of the Universidade Federal de Campina Grande, Paraíba State, Brazil. In order to determine the MIC of the selected phytocompounds, bacterial strains of E. coli ESBL (C-18, C-21, C-20, C-24, C-25, 24, 65) from outpatients were used, and microdilution technique in 96-hole reaction plate by two-fold serial dilution, reserving the last column for growth control of microorganisms.
RESULTS:
MIC of carvacrol showed concentrations of 64 ?g/mL for strain 65 and 128 ?g/mL for strains C-18, C-20, C-21, C-24, C-25, and 24. In the thymol action, MIC was determined as 1,024 ?g/mL for strain C-25; 512 ?g/mL for C-18, C-21, 24, and 65; 256 ?g/mL for C-24; and 128 ?g/mL for strain C-20.
CONCLUSION:
Through the experiments it was possible to affirm that the phytocompounds carvacrol and thymol have bacteriostatic effects on E. coli strains