A substituição His131Arg no gene FCGR2A (rs1801274) não está associada à gravidade da infecção por influenza A (H1N1) pdm09/The His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1)pdm09 infection
Maestri, Alvino; Sortica, Vinicius Albuquerque; Ferreira, Deimy Lima; Ferreira, Jessylene de Almeida; Amador, Marcos Antônio Trindade; Mello, Wyller Alencar de; Santos, Sidney Emanuel Batista; Sousa, Rita Catarina Medeiros.
BMC Res Notes
; 9(296): 1-4, 2016. tab
Artigo
em Inglês
| Instituto Evandro Chagas (SOPHIA) | ID: iec-16225
Background:
The virulence and pathogenicity of different influenza strains are responsible for a more or less severe disease. Recent studies have attempted to understand how host genetic factors may influence the clinical presentation of the disease. In the present study, the His131Arg (rs1801274) polymorphism was investigated in individuals from a Brazilian admixed population with a diagnosis of influenza A(H1N1)pdm09 infection.Methods:
In the present study, the influence of the His131Arg (rs1801274) polymorphism, a variant of the FCGR2A gene, was investigated in 436 patients with a diagnosis of influenza A(H1N1)pdm09, evaluated at health services in the northern and northeastern regions of Brazil between June 2009 and August 2010. Patients were divided into a group of non-hospitalized patients (n = 192) and a group of hospitalized patients (n = 244; 100 of them died).Results:
No significant difference in the allele or genotype frequencies of the rs1801274 polymorphism was observed between groups (p = 0.952 and p = 0.388). Multinomial logistic regression showed no effect of the rs1801274 polymorphism on severity or death of patients from the Brazilian admixed population (p = 0.368 and p = 0.469).Conclusions:
The rs1801274 polymorphism is not associated with severe disease in patients infected with influenza A(H1N1)pdm09
Biblioteca responsável:
BR275.1
Localização: PCIEC2016 / BR275.1
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