High incidence of rhinovirus infection in children with community-acquired pneumonia from a city in the Brazilian pre-Amazon region
Ferreira, Hivylla L. dos Santos; Costa, Karla Luana P; Cariolano, Marilha S; Oliveira, Gustavo S; Felipe, Karen K. P; Silva, Elen S. A; Alves, Matheus S; Maramaldo, Carlos Eduardo C; Sousa, Eduardo M. de; Rego, Joseany S; Silva, Ilana C. P. A; Albuquerque, Rejane K. S; Araújo, Nathalya S. C; Amorim, Angela M. M; Costa, Luciane D; Pinheiro, Claudiana S; Guimarães, Vinícius A; Santos, Mirleide Cordeiro dos; Mello, Wyller Alencar de.
FERREIRA, Hivylla L. dos Santos et al. High incidence of rhinovirus infection in children with community-acquired pneumonia from a city in the Brazilian pre-Amazon region. Journal of Medical Virology, v. 91, n. 10, p. 1751-1758, Oct. 2019. DOI: https://doi.org/10.1002/jmv.25524. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166869/pdf/JMV-91-1751.pdf.
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em Inglês
| Instituto Evandro Chagas (DSpace) | ID: ied-3850
Communityacquired pneumonia (CAP) is the leading cause of child death worldwide. Viruses are the most common pathogens associated with CAP in children, but their incidence varies greatly. This study investigated the presence of respiratory syncytial virus (RSV), adenovirus, human rhinovirus (HRV), human metapneumovirus (HMPV), human coronavirus (HCoVOC43 and HCoVNL63), and influenza A virus (FluA) in children with CAP and the contributing risk factors. Here, children with acute respiratory infections were screened by pediatrics; and a total of 150 radiographicallyconfirmed CAP patients (aged 3 months to 10 years) from two clinical centers in Sao Luis, Brazil were recruited. Patient's clinical and epidemiological data were recorded. Nasopharyngeal swab and tracheal aspirate samples were collected to extract viral nucleic acid. RSV, adenovirus, rhinovirus, FluA, HMPV, HCoVOC43, and HCoVNL63 were detected by realtime polymerase chain reaction. The severe CAP was associated with ages between 3 and 12 months. Viruses were detected in 43% of CAP patients. Rhinovirus infections were the most frequently identified (68%). RSV, adenovirus, FluA, and coinfections were identified in 14%, 14%, 5%, and 15% of children with viral infection, respectively. Rhinovirus was associated with nonsevere CAP (P = .014); RSV, FluA, and coinfections were associated with severe CAP (P < .05). New strategies for prevention and treatment of viral respiratory infections, mainly rhinovirus and RSV infections, are necessary. / Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão. Grant Number #PPSUS03384/13
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