Molecular analysis of G3P[6] rotavirus in the Amazon region of Brazil: evidence of reassortment with equine-like strains
SERRA, Ana C. Silva et al. Molecular analysis of G3P[6] rotavirus in the Amazon region of Brazil: evidence of reassortment with equine-like strains. Future Microbiology, v. 16, n. 12, p. 847-862, July 2021.
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ABSTRACT
Aim:
To perform a molecular analysis of rotavirus A (RVA) G3P[6] strains detected in 2012 and 2017 in the Amazon region of Brazil. Materials &methods:
Eighteen RVA G3P[6] strains were collected from children aged under 10 years hospitalized with acute gastroenteritis, and partial sequencing of each segment genome was performed using Sanger sequencing.Results:
Phylogenetic analysis showed that all G3P[6] strains had a DS-1-like genotype constellation. Two strains had the highest nucleotide identities with equine-like G3P[6]/G3P[8] genotypes. Several amino acid alterations in VP4 and VP7 neutralizing epitopes of equine-like RVA G3P[6] strains were observed in comparison with vaccine strains.Conclusion:
These findings suggest that equine-like RVA G3P[6] strains have been circulating in the Amazon region of Brazil as a result of direct importation, and support natural RVA evolutionary mechanisms. / Instituto Evandro Chagas. Secretaria de Vigilância em Saúde. Ministério da Saúde.
Texto completo:
1
Coleções IEC:
Producao_cientifica
Base de dados:
IED
Assunto principal:
Filogenia
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Rotavirus
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Diarreia
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Betacoronavirus 1
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Gastroenterite
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Genótipo
País/Região como assunto:
America do sul
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Brasil
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article