Simultaneous occurrence of Epstein-Barr virus (EBV) in periodontal pockets and in oral squamous cell carcinoma: a cross-sectional study

Santos, Humberto Jácome; Silva, Naira da Silva e; Resende, Renata Gonçalves; Pinheiro, Helder Henrique Costa; Machado, Luiz Fernando Almeida; Silva, Guilherme de Souza; Costa, Fernando de Oliveira; Costa, Igor Brasil; Alves, Ana Cláudia Braga Amoras; Mesquita, Ricardo Alves; Alves Júnior, Sérgio de Melo

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Simultaneous occurrence of Epstein-Barr virus (EBV) in periodontal pockets and in oral squamous cell carcinoma: a cross-sectional study

Santos, Humberto Jácome; Silva, Naira da Silva e; Resende, Renata Gonçalves; Pinheiro, Helder Henrique Costa; Machado, Luiz Fernando Almeida; Silva, Guilherme de Souza; Costa, Fernando de Oliveira; Costa, Igor Brasil; Alves, Ana Cláudia Braga Amoras; Mesquita, Ricardo Alves; Alves Júnior, Sérgio de Melo.

SANTOS, Humberto Jácome et al. Simultaneous occurrence of Epstein-Barr virus (EBV) in periodontal pockets and in oral squamous cell carcinoma: a cross-sectional study. Clinical Oral Investigations, v. 26, n. 3, p. 2807-2815, 2022.

Artigo em Inglês | Instituto Evandro Chagas (DSpace) | ID: ied-4478

Objectives:

This study aimed to investigate the detection of Epstein-Barr virus (EBV) in oral squamous cell carcinoma (OSCC) and to verify the concordance of EBV-DNA frequency in subgingival sites and in the OSCC.

Methods:

A cross-sectional study with 30 OSCC patients, aged from 44 to 88 years old, was conducted. Samples were collected in subgingival sites and at the OSCC, then submitted to DNA isolation, qPCR, and genotyping. Descriptive statistic was performed to report the frequency of EBV-DNA in all samples, and McNemar test was applied to verify the concordance among the EBV-DNA frequency in both sites.

Results:

The individuals presented 62 years old in average, and the majority were male (66.6%). EBV-DNA was detected in 56.7% OSCC lesions. Among the subgroup of 19 dentate individuals, high concordance (73.7%) in both EBV-DNA detection and the absence in subgingival sites and OSCC was observed, and it was statistically significant (p < 0.05).

Conclusions:

We report the notable occurrence of EBV-DNA in OSCC; also, the presence of EBV in periodontal sites may contribute to find it in OSCC, although the possible contribution of EBV in the OSCC remains to be investigated. / CAPES/coordenação de aperfeiçoamento de pessoal de nível superior Finance Code 001/coordenação de aperfeiçoamento de pessoal de nível superior

Assuntos

Periodontite/virologia Herpesvirus Humano 4 Infecções por Vírus Epstein-Barr/virologia Neoplasias Bucais Bolsa Periodontal

BVS IEC

Instituto Evandro Chagas

Formato de exportação:

Simultaneous occurrence of Epstein-Barr virus (EBV) in periodontal pockets and in oral squamous cell carcinoma: a cross-sectional study

Objectives:

Methods:

Results:

Conclusions:

Assuntos