Association between SNPs in microRNAs and microRNAs-Machinery genes with susceptibility of leprosy in the amazon population
Silva, Mayara Natália Santana da; Leal, Diana Feio da Veiga Borges; Sena, Camille; Pinto, Pablo; Gobbo, Angélica Rita; Silva, Moises Batista da; Salgado, Claudio Guedes.
SILVA, Mayara Natália Santana da et al. Association between SNPs in microRNAs and microRNAs-Machinery genes with susceptibility of leprosy in the amazon population. International Journal of Molecular Sciences, v. 23, n. 18, p. 1-12, 2022. DOI: https://doi.org/10.3390/ijms231810628. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503809/pdf/ijms-23-10628.pdf.
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em Inglês
| Instituto Evandro Chagas (DSpace) | ID: ied-4673
Leprosy is a chronic neurodermatological disease caused by the bacillus Mycobacterium leprae. Recent studies show that SNPs in genes related to miRNAs have been associated with several diseases in different populations. This study aimed to evaluate the association of twenty-five SNPs in genes encoding miRNAs related to biological processes and immune response with susceptibility to leprosy and its polar forms paucibacillary and multibacillary in the Brazilian Amazon. A total of 114 leprosy patients and 71 household contacts were included in this study. Genotyping was performed using TaqMan Open Array Genotyping. Ancestry-informative markers were used to estimate individual proportions of case and control groups. The SNP rs2505901 (pre-miR938) was associated with protection against the development of paucibacillary leprosy, while the SNPs rs639174 (DROSHA), rs636832 (AGO1), and rs4143815 (miR570) were associated with protection against the development of multibacillary leprosy. In contrast, the SNPs rs10739971 (pri-let-7a1), rs12904 (miR200C), and rs2168518 (miR4513) are associated with the development of the paucibacillary leprosy. The rs10739971 (pri-let-7a1) polymorphism was associated with the development of leprosy, while rs2910164 (miR146A) and rs10035440 (DROSHA) was significantly associated with an increased risk of developing multibacillary leprosy. / The Brazilian National Research Council (CNPq) 407922/2021- 0, the Coordination for Higher Education Personnel Training (CAPES) 3381/2013, the Amazonian Research Foundation (FAPESPA), the VALE S.A. 27756/2019 and by the PROPESP/PROEX/UFPA.
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