Genome sequencing of dengue virus serotype 4 in a bat brain sample (Platyrrhinus helleri) from the Brazilian Amazon
Franco Filho, Luciano Chaves; Barata, Rafael Ribeiro; Coelho, Mônica Silva; Cardoso, Jedson Ferreira; Lemos, Poliana da Silva; Reis, Herald Souza dos; Favacho, Joana da Felicidade Ribeiro; Faria, Nuno Rodrigues; Nunes, Márcio Roberto Teixeira.
FRANCO FILHO, Luciano Chaves et al. Genome sequencing of dengue virus serotype 4 in a bat brain sample (Platyrrhinus helleri) from the Brazilian Amazon. Infection, Genetics and Evolution, v. 109, n. 105407, p. 1-5, Apr. 2023. DOI: https://doi.org/10.1016/j.meegid.2023.
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em Inglês
| Instituto Evandro Chagas (DSpace) | ID: ied-6728
The existence of sylvatic transmission of dengue virus in communities of neotropical bats remains uncertain. In this work we present a near-complete genome of dengue virus serotype 4 obtained from the brain sample of a bat from Platyrrhinus helleri specie collected in the Brazilian Amazon region. The presence of the virus in the brain sample may indicate a possible tropism for the central nervous system in bats, which may justify negative results in previous studies that focused on analysis of other tissues, such as liver and spleen. Besides the duration of dengue virus circulation in the Americas (circa 40 years) may be too short for an implementation of a sylvatic dengue virus cycle. Our findings suggest that continued monitoring is needed to confirm with the neotropical bats could potentially act as a natural reservoir of dengue in the region / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES - grant number 3274/2013) and National Council for Scientific and Technological Development (CNPq - grant number 302584/2015-3). NRF was supported by a Wellcome Trust and Royal Society Sir Henry Dale Fellowship (204311/Z/16/Z) and by a Medical Research Council-São Paulo Research Foundation (FAPESP) CADDE partnership award (MR/S0195/1 and FAPESP 18/14389-0)
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