Endemic high-risk clone ST277 is related to the spread of SPM-1-producing Pseudomonas aeruginosa during the COVID-19 pandemic period in northern Brazil
Santos, Pabllo Antonny Silva dos; Rodrigues, Yan Corrêa; Marcon, Davi Josué; Lobato, Amália Raiana Fonseca; Cazuza, Thalyta Braga; Gouveia, Maria Isabel Montoril; Silva, Marcos Jessé Abrahão; Souza, Alex Brito; Lima, Luana Nepomuceno Gondim Costa; Quaresma, Ana Judith Pires Garcia; Brasiliense, Danielle Murici; Lima, Karla Valéria Batista.
SANTOS, Pabllo Antonny Silva dos et al. Endemic high-risk clone ST277 is related to the spread of SPM-1-producing Pseudomonas aeruginosa during the COVID-19 pandemic period in northern Brazil. Microorganisms, v. 11, n. 8, p. 1-15, 2023. DOI: https://doi.org//10.3390/microorganisms11082069. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457858/pdf/microorganisms-11-02069.pdf.
Artigo
em Inglês
| Instituto Evandro Chagas (DSpace) | ID: ied-6926
Pseudomonas aeruginosa is a high-priority bacterial agent that causes healthcare-acquired infections (HAIs), which often leads to serious infections and poor prognosis in vulnerable patients. Its increasing resistance to antimicrobials, associated with SPM production, is a case of public health concern. Therefore, this study aims to determine the antimicrobial resistance, virulence, and genotyping features of P. aeruginosa strains producing SPM-1 in the Northern region of Brazil. To determine the presence of virulence and resistance genes, the PCR technique was used. For the susceptibility profile of antimicrobials, the KirbyBauer disk diffusion method was performed on MuellerHinton agar. The MLST technique was used to define the ST of the isolates. The exoS+/exoU− virulotype was standard for all strains, with the aprA, lasA, toxA, exoS, exoT, and exoY genes as the most prevalent. All the isolates showed an MDR or XDR profile against the six classes of antimicrobials tested. HRC ST277 played a major role in spreading the SPM-1-producing P. aeruginosa strains. / The APC was funded by Evandro Chaga Institute (IEC/PA). Yan Corrêa Rodrigues scholarship is funded by PDPGPós-Doutorado Estratégico (PDPG-POSDOC), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES/Edital 16/2022). Pabllo Antonny Silva Dos Santos is funded by CAPES
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