Antagonism of clonidine injected intracerebroventricularly in different models of salt intake
Braz. j. med. biol. res
; 29(12): 1663-6, Dec. 1996. graf
Article
em En
| LILACS
| ID: lil-188451
Biblioteca responsável:
BR1.1
ABSTRACT
Clonidine, and alpha2-adrenergic agonist, injected into the brain inhibits salt intake of animals treated by the diuretic model of sodium depletion. In the present study, we address the question of whether central injection of clonidine also inhibits salt intake in animals deprived of water or in the need-free state. Saline or clonidine (30 nmol) was injected into the anterior third ventricle of 24-h sodium-depleted (furosemide + removal of ambient sodium), of 24-h water-deprived and of normovolemic (need-free state) adult male rats. Clonidine injected intracerebroventricularly (icv) inhibited the 1.5 per cent NaCl intake for 120 min by 50 to 90 per cent in every model tested. Therefore, different models of salt intake are inhibited by icv injection of clonidine. Idazoxan, an alpha2-adrenergic antagonist, injected icv at a dose of 160 nmol, inhibited the effect of clonidine only in the furosemide + removal of ambient sodium model of salt intake. This indicates that the antagonism of this effect by idazoxan is dependent on the body fluid/sodium status of the animal.
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Base de dados:
LILACS
Assunto principal:
Clonidina
/
Cloreto de Sódio na Dieta
/
Idazoxano
/
Dieta Hipossódica
/
Modelos Animais de Doenças
Limite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1996
Tipo de documento:
Article
/
Congress and conference
/
Project document