T cell-related memory
Ciênc. cult. (Säo Paulo)
; 46(5/6): 374-9, Sept.-Dec. 1994. graf
Article
em En
| LILACS
| ID: lil-199866
Biblioteca responsável:
BR1.1
RESUMO
Immunological memory is embodied in the rapid and enhanced immune responsiveness to antigens that have been previously encountered. In this work we have analyzed the development of humoral immunological memory to a conventional antigen (TNP-BSA) and a superantigen (staphylococcal enterotoxin B (SEB) in T cell-reconstituted athymic or euthymic mice. It was demonstrated that T cell reconstituded athymic mice, which lack recent thymic emigrants, mount a primary response to a T cell dependent antigen, but do not develop memory or the capacity to produce specific anti-TNP IgG1 antibodies during the secondary immune response. On the other hand, if thymocytes were continously provided during the secondary response a typical memory response was achieved, with the presence of high levels of specific IgG1. In addition, we have shown that immunization of mice with staphylococcal enterotoxin B (SEB) resulted in a detectable anti-SEB antibody response, which was further increased upon boosting. The typical secondary response do SEB was mainly composed of IgG1, thus suggesting the involvement of interleukin-4 (IL-4)-producing T cells. These results led us to propose that the development of humoral immunological memory can not be solely explained by the long lifespan of primed T lymphocytes, and a novel dynamic and systemic hypothesis is given to explain memory development.
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Base de dados:
LILACS
Assunto principal:
Linfócitos T
/
Memória Imunológica
Limite:
Animals
Idioma:
En
Revista:
Ciênc. cult. (Säo Paulo)
Assunto da revista:
CIENCIA
Ano de publicação:
1994
Tipo de documento:
Article