Comparison between sprague-dawley and wistar rats as an experimental model of pharmacokinetic alterations induced by spinal cord injury
Arch. med. res
; 27(4): 453-7, 1996. ilus, tab
Article
em En
| LILACS
| ID: lil-200347
Biblioteca responsável:
MX1.1
ABSTRACT
Two strains of rats, Sprague-Dawley and Wistar, were assayed in order to determine which strain is the more suitable experimental model for the study of pharmacokinetic alterations inuced by spinal cord injury. Animals were submitted to spinal cord contusion at the T8-T9 level by the weight drop method. A single acetaminophen oral dose (100 mg/kg) was administered 24 h after injury and blood samples were drawn for a period of 4 h. Acetaminophen concentration in whole blood was determined by high performance liquid chromatography and pharmacokinetic parameters were estimated. For both strains, Cmax and AUC were significantly lower, whereas tmax remained uchanged, in injured animals compared to sham-injured controls. Circulating acetaminophen concentrations were higher; therefore, pharmacokinetic alterations were more easily discerned, in Sprague-Dawley than in Wistar rats. It is concluded that the Sprague-Dawley strain is a more suitable model for the study of pharmacokinetic alternations induced by spinal cord injury
Buscar no Google
Base de dados:
LILACS
Assunto principal:
Traumatismos da Medula Espinal
/
Teofilina
/
Farmacocinética
/
Amicacina
/
Gentamicinas
/
Ratos Wistar
/
Ratos Sprague-Dawley
/
Modelos Animais de Doenças
/
Lorazepam
/
Acetaminofen
Limite:
Animals
Idioma:
En
Revista:
Arch. med. res
Assunto da revista:
MEDICINA
Ano de publicação:
1996
Tipo de documento:
Article