Effect of high-dose fentanyl on renal function in dogs
São Paulo med. j
; 115(3): 1433-9, May-Jun. 1997. tab, graf
Article
em En
| LILACS
| ID: lil-201562
Biblioteca responsável:
BR1.1
ABSTRACT
Our objective was to determine the effects of high-dose fentanyl on canine renal function (RF). We anesthetized with sodium pentobarbital (SP) 16 dogs, randomly divided into 2 groupsin G1, SP was given alone, and in G2, combined with 0.05 mg.kg(-1) fentanyl. All animals were ventilated artificially and had catheterized left and righ femoral veins and left femoral artery for fluid infusion, drug administration, blood collection, and hemodynamic measurement. Urine was collected throughout the experiment. Attributes of RF were studied. SP did not alter RF, which was significantly altered by fentanyl. In G2, slower heart rates, mean arterial pressure, creatinine clearance, urinary output, osmolar clearance and fractional excretion of sodium and potassium were observed. G1 had a behavior attributed to extracellular volume expansion and no RF alterations. In G2, we observed significant decreases in RF due to opioid-induced hemodynamic changes, not discarding the possible action of aldosterone.
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Fentanila
/
Adjuvantes Anestésicos
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Rim
Limite:
Animals
Idioma:
En
Revista:
São Paulo med. j
Assunto da revista:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
MEDICINA
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Ano de publicação:
1997
Tipo de documento:
Article