Opioides y sistema inmune / Opioids and the immune system
Rev. méd. Chile
; 127(3): 341-8, mar. 1999.
Article
em Es
| LILACS
| ID: lil-243801
Biblioteca responsável:
CL1.1
ABSTRACT
The immune response is partly regulated by the nervous system, that involves endogenous opioids, stimulating or depressing immune responses. Opioids modulate immune response by indirect and direct mechanisms. Indirect modulation occurs when the activation of opioid receptors within the nervous system modifies the activity of neuroendocrine axes or neurotransmission pathways. Direct modulation results from the effects of opioids on immune system cells. This requires the expression of membrane opioid receptors in these cells. Immunomodulating effects of morphine would be a result of the integration of indirect and direct effects. In animal models, morphine transiently depresses cellular and humoral immunity. In humans, morphine has similar effects; however, the real impact of morphine administration on the immune response in clinical situations in not yet known
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Base de dados:
LILACS
Assunto principal:
Sistema Imunitário
/
Entorpecentes
Limite:
Humans
Idioma:
Es
Revista:
Rev. méd. Chile
Assunto da revista:
MEDICINA
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Chile