Saccharin analysis in pharmaceutical and cosmetic preparations by derivative ultraviolet spectrophotometry

ABSTRACT

Saccharin, a synthetic sweetener constituent of several pharmaceutical and cosmetic preparations, is analyzed qualitatively and quantitatively in the presence of interferences like active ingredients and excipients. A derivative ultraviolet spectrophotometric method employing the second and the fourth orders was used. The calibration data obtained were satisfactory, with a relative precision range of 0.53 por cento-0,72 por cento, and linearity between 0.9998-0.9999.The recovery test results for the toothgel sample ranged between 97.80 por cento and 104.95 por cento in the second order of derivative and between 98.04 por cento and 101.32 por cento in the fourth derivative...