Clostridium perfringens tipo D é o agente etiológico da
enterotoxemia em
ruminantes , causada pela toxina épsilon e caracterizada por
edema cardíaco , pulmonar, renal e cerebral.
Anticorpos monoclonais contra toxina épsilon de C. perfringens tipo D foram produzidos a partir da fusão da linhagen de mieloma P3-X63-Ag8 653 com
células do
baço de
camundongos Balb/c imunizados com o
toxóide épsilon. Seis linhagens de híbridos secretores de
anticorpos monoclonais das classes e
IgM e
IgG foram estabelecidas.
Clostridium perfringens type D is the aetiological agent of
enterotoxemia in
ruminants . The
disease is caused by epsilon toxin characterized by cardiac, pulmonary,
kidney and
brain edema .
Monoclonal antibodies were produced by using myeloma
cell line P3-X63-Ag8 653 fused with
spleen cells from Balb/c
mice , immunized with epsilon
toxoid of C. perfringens type D. Six
hybrids were established secreting
monoclonal antibodies of the
IgM class and
IgG3 subclass.