Back to the future in Chagas disease: from animal models to patient cohort studies, progress in immunopathogenesis research
Mem. Inst. Oswaldo Cruz
; 104(supl.1): 187-198, July 2009.
Article
em En
| LILACS
| ID: lil-520879
Biblioteca responsável:
BR1.1
ABSTRACT
Despite the wealth of information generated by trans-disciplinary research in Chagas disease, knowledge about its multifaceted pathogenesis is still fragmented. Here we review the body of experimental studies in animal models supporting the concept that persistent infection by Trypanosoma cruzi is crucial for the development of chronic myocarditis. Complementing this review, we will make an effort to reconcile seemingly contradictory results concerning the immune profiles of chronic patients from Argentina and Brazil. Finally, we will review the results of molecular studies suggesting that parasite-induced inflammation and tissue damage is, at least in part, mediated by the activities of trans-sialidase, mucin-linked lipid anchors (TLR2 ligand) and cruzipain (a kinin-releasing cysteine protease). One hundred years after the discovery of Chagas disease, it is reassuring that basic and clinical research tends to converge, raising new perspectives for the treatment of chronic Chagas disease.
Palavras-chave
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Trypanosoma cruzi
/
Doença de Chagas
Tipo de estudo:
Etiology_studies
/
Observational_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Brasil