Differential tissue tropism of Trypanosoma cruzi strains: an in vitro study
Mem. Inst. Oswaldo Cruz
; 105(6): 834-837, Sept. 2010. graf
Article
em En
| LILACS
| ID: lil-560672
Biblioteca responsável:
BR1.1
ABSTRACT
We have previously demonstrated selection favoring the JG strain of Trypanosoma cruziin hearts of BALB/c mice that were chronically infected with an equal mixture of the monoclonal JG strain and a clone of the Colombian strain, Col1.7G2. To evaluate whether cell invasion efficiency drives this selection, we infected primary cultures of BALB/c cardiomyocytes using these same T. cruzi populations. Contrary to expectation, Col1.7G2 parasites invaded heart cell cultures in higher numbers than JG parasites; however, intracellular multiplication of JG parasites was more efficient than that of Col1.7G2 parasites. This phenomenon was only observed for cardiomyocytes and not for cultured Vero cells. Double infections (Col1.7G2 + JG) showed similar results. Even though invasion might influence tissue selection, our data strongly suggest that intracellular development is important to determine parasite tissue tropism.
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Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Trypanosoma cruzi
/
Tropismo
/
Miócitos Cardíacos
/
Interações Hospedeiro-Parasita
Limite:
Animals
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
2010
Tipo de documento:
Article