Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection
Fecury, Amanda Alves; Almeida, Marcella Kelly Costa de; Santos, Kemper Nunes dos; Freitas, Andrei da Silva; Dantas, Socorro de Fatima Loureiro; Costa, Carlos Araujo da; Crescente, Angelo Barlleta; Sousa, Rita Catarina Medeiros de; Brito, Elza Baia de; Nassiri, Reza; Lampe, Elizabeth; Martins, Luisa Caricio.
Rev. Soc. Bras. Med. Trop
; 47(1): 90-92, Jan-Feb/2014. tab
Artigo
em Inglês
| LILACS | ID: lil-703154
Introduction:
The genomic heterogeneity of hepatitis C virus (HCV) influences liver disorders. This study aimed to determine the prevalence of HCV genotypes and to investigate the influence of these genotypes on disease progression.Methods:
Blood samples and liver biopsies were collected from HCV-seropositive patients for serological analysis, biochemical marker measurements, HCV genotyping and histopathological evaluation.Results:
Hepatitis C virus-ribonucleic acid (HCV-RNA) was detected in 107 patients (90.6% with genotype 1 and 9.4% with genotype 3). Patients infected with genotype 1 exhibited higher mean necroinflammatory activity and fibrosis.Conclusions:
HCV genotype 1 was the most prevalent and was associated with greater liver dysfunction. .
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