Full-length infectious clone of a low passage dengue virus serotype 2 from Brazil
Santos, Jefferson José da Silva; Magalhães, Tereza; Silva Junior, José Valter Joaquim; Silva, Andréa Nazaré Monteiro Rangel da; Cordeiro, Marli Tenório; Gil, Laura Helena Vega Gonzales.
Mem. Inst. Oswaldo Cruz
; 110(5): 677-683, Aug. 2015. tab, ilus
Artigo
em Inglês
| LILACS | ID: lil-755902
Full-length dengue virus (DENV) cDNA clones are an invaluable tool for many studies, including those on the development of attenuated or chimeric vaccines and on host-virus interactions. Furthermore, the importance of low passage DENV infectious clones should be highlighted, as these may harbour critical and unique strain-specific viral components from field-circulating isolates. The successful construction of a functional Brazilian low passage DENV serotype 2 full-length clone through homologous recombination reported here supports the use of a strategy that has been shown to be highly useful by our group for the development of flavivirus infectious clones and replicons.
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