Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites
Mem. Inst. Oswaldo Cruz
; 110(8): 981-988, Dec. 2015. tab, graf
Article
em En
| LILACS
| ID: lil-769827
Biblioteca responsável:
BR1.1
ABSTRACT
This work reports the in vitro activity against Plasmodium falciparumblood forms (W2 clone, chloroquine-resistant) of tamoxifen-based compounds and their ferrocenyl (ferrocifens) and ruthenocenyl (ruthenocifens) derivatives, as well as their cytotoxicity against HepG2 human hepatoma cells. Surprisingly with these series, results indicate that the biological activity of ruthenocifens is better than that of ferrocifens and other tamoxifen-like compounds. The synthesis of a new metal-based compound is also described. It was shown, for the first time, that ruthenocifens are good antiplasmodial prototypes. Further studies will be conducted aiming at a better understanding of their mechanism of action and at obtaining new compounds with better therapeutic profile.
Palavras-chave
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Compostos Organometálicos
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Plasmodium falciparum
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Rutênio
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Compostos Ferrosos
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Complexos de Coordenação
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Antimaláricos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
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PARASITOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article
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Project document
País de afiliação:
Brasil