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Clinical and microbiological features of infections caused by Pseudomonas aeruginosa in patients hospitalized in intensive care units
Matos, Eliseth Costa Oliveira de; Matos, Haroldo José de; Conceição, Marília Lima; Rodrigues, Yan Corrêa; Carneiro, Irna Carla do Rosário Souza; Lima, Karla Valéria Batista.
Afiliação
  • Matos, Eliseth Costa Oliveira de; Universidade Federal do Pará. Programa de Pós-Graduação em Medicina Tropical. Núcleo de Medicina Tropical. Belém. BR
  • Matos, Haroldo José de; Universidade Federal do Pará. Programa de Pós-Graduação em Medicina Tropical. Núcleo de Medicina Tropical. Belém. BR
  • Conceição, Marília Lima; Universidade Federal do Pará. Programa de Pós-Graduação em Medicina Tropical. Núcleo de Medicina Tropical. Belém. BR
  • Rodrigues, Yan Corrêa; Universidade Federal do Pará. Programa de Pós-Graduação em Medicina Tropical. Núcleo de Medicina Tropical. Belém. BR
  • Carneiro, Irna Carla do Rosário Souza; Universidade Federal do Pará. Programa de Pós-Graduação em Medicina Tropical. Núcleo de Medicina Tropical. Belém. BR
  • Lima, Karla Valéria Batista; Universidade Federal do Pará. Programa de Pós-Graduação em Medicina Tropical. Núcleo de Medicina Tropical. Belém. BR
Rev. Soc. Bras. Med. Trop ; 49(3): 305-311, tab, graf
Article em En | LILACS | ID: lil-785790
Biblioteca responsável: BR1.1
ABSTRACT
Abstract

INTRODUCTION:

The spread of multidrug-resistant Pseudomonas aeruginosa in Brazilian hospitals has greatly impacted upon the morbidity and mortality of individuals in intensive care units. Given the lack of information regarding the dynamics of multidrug resistance in northern Brazil, we analyzed the clinical and microbiological features of nosocomial infections caused by P. aeruginosa. METHODS Between January 2010 and March 2012, we conducted a retrospective cohort study of P. aeruginosa isolates from 54 patients who were hospitalized in intensive care units. The clinical and epidemiologic variables were analyzed, including the patients' demographic data and comorbidities, and the lengths of the intensive care unit stays, the classification of the infections as nosocomial, the use of invasive procedures, antimicrobial therapy, and the patients' outcomes. We undertook susceptibility tests, molecular detection of the metallo-β-lactamase genes, and genotypic analyses of the isolates using the repetitive element-polymerase chain reaction.

RESULTS:

Multidrug resistance occurred most frequently among isolates from adults who had been hospitalized for an average of 87.1 days. The use of mechanical ventilation and urinary catheters were risk factors for infection. The four isolates that harbored the blaSPM-1-like gene showed >95% genetic similarity. CONCLUSIONS This study's findings show that P. aeruginosa has a high death rate, and that inadequate treatment and invasive procedures are risk factors for infection. This is the first report describing the detection of the blaSPM-1-like gene in northern Brazil. These results highlight the need for better monitoring and a greater understanding of nosocomial infections and their public health impacts.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: LILACS Assunto principal: Pseudomonas aeruginosa / Infecções por Pseudomonas / Beta-Lactamases / Infecção Hospitalar / Antibacterianos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Newborn País/Região como assunto: America do sul / Brasil Idioma: En Revista: Rev. Soc. Bras. Med. Trop Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Base de dados: LILACS Assunto principal: Pseudomonas aeruginosa / Infecções por Pseudomonas / Beta-Lactamases / Infecção Hospitalar / Antibacterianos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Newborn País/Região como assunto: America do sul / Brasil Idioma: En Revista: Rev. Soc. Bras. Med. Trop Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil