Effects of murine tumors on delayed hypersensitivity to dinitrochlorobenzene. I. Description of anergy caused by transplanted tumors.
J Natl Cancer Inst
; 57(5): 1077-84, 1976 Nov.
Article
em En
| MEDLINE
| ID: mdl-1003543
ABSTRACT
In the murine model presented for tumor-associated immune suppression, normal BALB/c mice displayed significant foodpad swelling when sensitized on the flank with 2 mg dinitrochlorobenzene (DNCB) dissolved in dimethyl sulfoxide and challenged in a footpad with 0.05 mg DNCB 10 days later. This reaction in challenged footpads seemed to be a classic delayed hypersensitivity reaction, since it took 24 hours to develop and included an extensive mononuclear infiltrate. The reaction was transmissible from sensitized to normal mice by the transfer of lymphoid cells but not to serum. When sensitized 10 days after tumor inoculation, mice bearing either an allogeneic melanoma or a syngeneic lymphoma or fibrosarcoma did not demonstrate delayed hypersensitivity to DNCB.
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Base de dados:
MEDLINE
Assunto principal:
Dinitroclorobenzeno
/
Hipersensibilidade Tardia
/
Tolerância Imunológica
/
Neoplasias Experimentais
/
Nitrobenzenos
Limite:
Animals
Idioma:
En
Revista:
J Natl Cancer Inst
Ano de publicação:
1976
Tipo de documento:
Article