Premature centromere division in patients with multiple endocrine neoplasia type 1.
Cancer Genet Cytogenet
; 109(2): 138-40, 1999 Mar.
Article
em En
| MEDLINE
| ID: mdl-10087948
ABSTRACT
Frequency of mitoses with premature centromere division (PCD) was examined in lymphocytes from subjects with multiple endocrine neoplasia type 1 (MEN 1). An increase in PCD after exposure to an alkylating agent was observed in subjects with MEN 1 who carry a heterozygous MEN1 gene mutation but not in normal controls or in affected subjects without the MEN1 gene mutation. These findings support the inclusion of MEN 1 as a chromosome instability syndrome and recognition of PCD as a manifestation of chromosome instability. Furthermore, these results suggest that the MEN1 gene product may function to maintain the integrity of DNA.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Centrômero
/
Proteínas Proto-Oncogênicas
/
Neoplasia Endócrina Múltipla Tipo 1
Limite:
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Cancer Genet Cytogenet
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Japão