Gamma hydroxybutyrate in the monkey. III. Effect of intravenous anticonvulsant drugs.
Neurology
; 28(11): 1173-8, 1978 Nov.
Article
em En
| MEDLINE
| ID: mdl-101897
ABSTRACT
Monkeys were treated intravenously with various anticonvulsant drugs before and after the intravenous administration of gamma hydroxybutyrate (GHB). Continuous electroencephalographic (EEG) and temperature monitoring was performed throughout all experiments. The GHB-induced EEG changes were abolished by ethosuximide and clonazepam, marginally improved by diazepam, and unaffected by phenobarbital. The GHB-induced myoclonic jerks were abolished by ethosuximide, significantly improved by diazepam, and worsened by clonazepam. Phenobarbital was effective in diminishing the frequency of GHB-induced myoclonic jerks only when given prior to administration of GHB. The GHB-induced stupor was improved only by ethosuximide. The GHB model of petit mal seizures is quite specific for drugs used in this disorder. GHB may play a role in the pathogenesis of absence seizures in children.
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Base de dados:
MEDLINE
Assunto principal:
Convulsões
/
Anticonvulsivantes
Limite:
Animals
Idioma:
En
Revista:
Neurology
Ano de publicação:
1978
Tipo de documento:
Article