N-acetyltransferase 1 genetic polymorphism influences the risk of prostate cancer development.
Cancer Lett
; 136(1): 83-7, 1999 Feb 08.
Article
em En
| MEDLINE
| ID: mdl-10211944
ABSTRACT
The potential involvement of N-acetyltransferase 1 (NAT1) genetic polymorphisms in prostate cancer (PCa) patients was analyzed in 101 patients with PCa and 97 controls with no incidental malignancy. Identification of NAT1*10, the variant allele associated with the rapid acetylator phenotype was by allele-specific polymerase chain reaction (PCR). When the NAT1*10 heterozygote and other genotypes without NAT1*10 allele were considered as low risk genotypes, NAT1*10/NAT1*10 had a significantly higher risk of PCa (OR = 2.4, 95% CI; 1.0-5.6). If our preliminary results can be confirmed in a larger population, it may be a useful marker for PCa risk.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Neoplasias da Próstata
/
Arilamina N-Acetiltransferase
/
Biomarcadores Tumorais
/
Isoenzimas
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
/
Male
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Japão