Zinc-catalyzed sulfur alkyation:insights from protein farnesyltransferase.
Curr Opin Chem Biol
; 3(2): 176-81, 1999 Apr.
Article
em En
| MEDLINE
| ID: mdl-10226042
ABSTRACT
Zinc metalloenzymes catalyze many important cellular reactions. Recently, the involvement of zinc in the catalysis of alkylation of sulfur groups has gained prominence. Current studies of the zinc metalloenzyme protein farnesyltransferase have shed light on its structure and catalytic mechanism, as well as the general mechanism of zinc-catalyzed sulfur alkylation.
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Base de dados:
MEDLINE
Assunto principal:
Enxofre
/
Zinco
/
Alquil e Aril Transferases
Idioma:
En
Revista:
Curr Opin Chem Biol
Assunto da revista:
BIOQUIMICA
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos