MRI visualization of proteoglycan depletion in articular cartilage via intravenous administration of Gd-DTPA.
Magn Reson Imaging
; 17(4): 577-83, 1999 May.
Article
em En
| MEDLINE
| ID: mdl-10231184
ABSTRACT
The effect of intravenous administration of gadolinium diethylenetriamine-pentaacetic acid (Gd-DTPA) on MR images was studied in vitro, using pathologic osteochondral specimens removed during surgery for total endoprosthesis, and in vivo, on a group of volunteers. In ex vivo specimens, lesions of different shape having lower T1 were detected which corresponded to areas with depleted proteoglycans found histologically. In vivo experiments on young volunteers showed that the time course of cartilage enhancement was different for different anatomies. The time for maximum enhancement ranged from 45 min for the ventral femoral condyle to 270 min for patellar cartilage.
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Base de dados:
MEDLINE
Assunto principal:
Proteoglicanas
/
Imageamento por Ressonância Magnética
/
Cartilagem Articular
/
Meios de Contraste
/
Gadolínio DTPA
/
Osteoartrite do Joelho
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Magn Reson Imaging
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Áustria