Angiotensin II, type 2 receptor in the development of vesico-ureteric reflux.
BJU Int
; 83(3): 318-22, 1999 Feb.
Article
em En
| MEDLINE
| ID: mdl-10233502
ABSTRACT
OBJECTIVE:
To investigate if mutation of the angiotensin II (Ang II) receptors AT2 is involved in primary vesico-ureteric reflux (VUR) in humans. PATIENTS ANDMETHODS:
Genetic polymorphisms in the AT1 and AT2 receptors was evaluated in 23 patients having the most common congenital urological abnormality, namely primary congenital VUR. The occurrence of the A1166C transition in the AT1 receptor gene and the A-1332G transition in the AT2 receptor gene were evaluated and compared with the incidence in normal controls with no urological abnormalities.RESULT:
The distribution of the AT1 receptor genotypes was no different between patients with VUR and healthy controls. Furthermore, 10 of 23 (44%) patients with VUR and seven of 19 (42%) controls carried the AT2 receptor gene variation. These results contrast with our previous finding of an association between the A-1332G transition in the AT2 receptor gene and primary obstructive megaureter, and pelvi-ureteric junction obstruction.CONCLUSIONS:
We propose that while the AT2 receptor is crucial for the normal development of the ureter, it does not contribute to the processes which culminate in VUR, which is primarily an abnormality in the bladder trigone.
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Base de dados:
MEDLINE
Assunto principal:
Refluxo Vesicoureteral
/
Receptores de Angiotensina
Limite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
BJU Int
Assunto da revista:
UROLOGIA
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Alemanha