Ex-chiral pool synthesis and pharmacological aspects of 3-pyrrolidinylisoxazoles.
Pharmazie
; 54(4): 248-50, 1999 Apr.
Article
em En
| MEDLINE
| ID: mdl-10234735
ABSTRACT
Employing the dopamine autoreceptor agonist (-)-3-PPP (3) as well as the cholinergic receptor ligands 4 and 5 as lead compounds the 3-pyrrolidinylisoxazoles 2a,b as well as its optical antipodes ent 2a,b were synthesized from (R)-aspartic acid (6) and (S)-aspartic acid (ent-6), respectively. Pharmacological properties of the target compounds were evaluated employing dopamine D2 receptor binding studies and functional experiments on muscarinic M2 receptors.
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Base de dados:
MEDLINE
Assunto principal:
Pirrolidinas
/
Receptores Muscarínicos
/
Receptores de Dopamina D2
/
Isoxazóis
Limite:
Animals
Idioma:
En
Revista:
Pharmazie
Assunto da revista:
FARMACIA
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Alemanha