Intraoperative optimized inverse planning for prostate brachytherapy: early experience.
Int J Radiat Oncol Biol Phys
; 44(4): 801-8, 1999 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-10386636
ABSTRACT
PURPOSE:
To demonstrate the feasibility of an intraoperative inverse planning technique with advanced optimization for prostate seed implantation. METHODS AND MATERIALS We have implemented a method for optimized inverse planning of prostate seed implantation in the operating room (OR), based on the genetic algorithm (GA) driven Prostate Implant Planning Engine for Radiotherapy (PIPER). An integrated treatment planning system was deployed, which includes real-time ultrasound image acquisition, treatment volume segmentation, GA optimization, real-time decision making and sensitivity analysis, isodose and DVH evaluation, and virtual reality navigation and surgical guidance. Ten consecutive patients previously scheduled for implantation were included in the series.RESULTS:
The feasibility of the technique was established by careful monitoring of each step in the OR and comparison with conventional preplanned implants. The median elapsed time for complete image capture, segmentation, GA optimization, and plan evaluation was 4, 10, 2.2, and 2 min, respectively. The dosimetric quality of the OR-based plan was shown to be equivalent to the corresponding preplan.CONCLUSION:
An intraoperative optimized inverse planning technique was developed for prostate brachytherapy. The feasibility of the method was demonstrated through an early clinical experience.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Algoritmos
/
Planejamento da Radioterapia Assistida por Computador
/
Braquiterapia
Tipo de estudo:
Diagnostic_studies
/
Guideline
/
Health_economic_evaluation
/
Prognostic_studies
Limite:
Humans
/
Male
Idioma:
En
Revista:
Int J Radiat Oncol Biol Phys
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos