Imprinted methylation and its effect on expression of the mouse Zfp127 gene.
Gene
; 234(2): 323-7, 1999 Jul 08.
Article
em En
| MEDLINE
| ID: mdl-10395905
ABSTRACT
The Zfp127 gene is located on mouse chromosome 7 in an imprinted region that is homologous to the 2-Mb Prader-Willi and Angelman Syndromes region on human chromosome 15q11-q13. Here, we show that the gene is differentially methylated, the maternal allele being methylated and the paternal allele being unmethylated. This maternal methylation is established promptly after fertilization prior to syngamy. We also provide data that demonstrate the significance of methylation in the paternal expression of the gene. The expression of the Zfp127 gene in methyltransferase-deficient mice is significantly higher, suggesting that the gene is biallelically expressed in these mice. The data presented here will help to understand the mechanism by which the monoallelic expression of the entire 2-Mb Prader-Willi and Angelman Syndrome region is regulated.
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Base de dados:
MEDLINE
Assunto principal:
Ribonucleoproteínas
/
Impressão Genômica
/
Metilação de DNA
Limite:
Animals
Idioma:
En
Revista:
Gene
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Israel