Concentration- and time-dependent effects of gamma-linolenic acid supplementation to tumor cells in culture.
Prostaglandins Leukot Essent Fatty Acids
; 60(4): 235-41, 1999 Apr.
Article
em En
| MEDLINE
| ID: mdl-10397404
ABSTRACT
Gamma-linolenic acid (GLA) supplemented to neuroblastoma SK-N-BE, tubal carcinoma TG and colon carcinoma SW-620 cells was incorporated into phospholipids in all the cell lines (although to different extents), in a concentration- and time-dependent manner. All the cell lines were able to metabolize GLA to arachidonic acid, SK-N-BE being the most active. Supplementation with low GLA concentrations for short periods was not sufficient to impair cell proliferation; only higher amounts of GLA had an anti-proliferative effect also in short times. In these conditions, the antiproliferative effect of GLA is probably due to cellular dysfunction caused by fatty acid modifications.
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Base de dados:
MEDLINE
Assunto principal:
Ácido gama-Linolênico
Limite:
Humans
Idioma:
En
Revista:
Prostaglandins Leukot Essent Fatty Acids
Assunto da revista:
ENDOCRINOLOGIA
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Itália