Trisomy 18 in Kuwait.
Int J Epidemiol
; 28(4): 711-6, 1999 Aug.
Article
em En
| MEDLINE
| ID: mdl-10480700
ABSTRACT
PIP: This paper describes associated factors of trisomy 18 (T18) or Edwards' syndrome among infants in Kuwait. A case control study of 131 normal newborn controls was undertaken. The study included information about gender, maternal age, paternal age, birth order, reproductive history, consanguinity, survival, and associated anomalies. Results showed a preponderance of females among T18 cases (female/male ratio, 2.1:1). The difference between the T18-case mothers and the control-group mothers was statistically significant (P = 0.002); however, there was no significant difference with regard to paternal age. The logistic regression analysis showed that the odds ratio for 2 abortions with reference to (0/1) abortion was 1.086, which is statistically significant as a risk for T18. The majority of children with T18 died before the second week of life. With regard to malformations, the most common associated anomalies were congenital heart and gastrointestinal abnormalities. Thus, the prevalence of T18 is high in Kuwait, with advanced maternal age as a significant risk factor.
Palavras-chave
Age Factors; Arab Countries; Asia; Case Control Studies; Chromosome Abnormalities; Demographic Factors; Developing Countries; Diseases; Infant; Kuwait; Maternal Age; Neonatal Diseases And Abnormalities; Parental Age; Paternal Age; Population; Population Characteristics; Research Methodology; Research Report; Studies; Western Asia; Youth
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Base de dados:
MEDLINE
Assunto principal:
Trissomia
/
Anormalidades Múltiplas
/
Cromossomos Humanos Par 18
/
Aberrações Cromossômicas
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
/
Newborn
/
Pregnancy
País/Região como assunto:
Asia
Idioma:
En
Revista:
Int J Epidemiol
Ano de publicação:
1999
Tipo de documento:
Article