NMDA receptor-mediated control of GABA release from neurointermediate lobes of female and male rats.
Brain Res
; 842(2): 469-72, 1999 Sep 25.
Article
em En
| MEDLINE
| ID: mdl-10526144
ABSTRACT
The effect of glutamate (GLUT) and its ionotropic receptor agonists on K(+)-evoked GABA release from the neurointermediate lobe (NIL) was investigated in diestrus, ovariectomized, ovariectomized-estrogenized female rats and intact male rats. GLUT and N-methyl-D-aspartate (NMDA) increased K(+)-evoked GABA release from the NIL in all the experimental groups. This stimulatory effect of NMDA was blocked by specific NMDA receptor antagonists but not by non-NMDA receptor antagonists. However, kainate did not modify evoked GABA release from the NIL in any of these groups. Neither GLUT nor NMDA modified nitric oxide synthase activity. These results indicate that GLUT, acting through NMDA receptors, stimulates evoked GABA release from the NIL of female and male rats. This effect is not influenced by gonadal status and does not appear to be mediated by nitric oxide production.
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Base de dados:
MEDLINE
Assunto principal:
Neuro-Hipófise
/
N-Metilaspartato
/
Receptores de N-Metil-D-Aspartato
/
Ácido Glutâmico
/
Estradiol
/
Ácido gama-Aminobutírico
Limite:
Animals
Idioma:
En
Revista:
Brain Res
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Argentina