Akinetopsia from nefazodone toxicity.
Am J Ophthalmol
; 128(4): 530-1, 1999 Oct.
Article
em En
| MEDLINE
| ID: mdl-10577608
ABSTRACT
PURPOSE:
To investigate two cases of selective impairment of motion perception (akinetopsia) induced by toxicity from the antidepressant nefazodone, a new drug that blocks serotonin reuptake and antagonizes 5-HT2 receptors.METHODS:
Case reports.RESULTS:
A 47-year-old man receiving nefazodone (Serzone; Bristol-Meyers Squibb, New York, N.Y.) (100 mg twice daily), reported a bizarre derangement of motion perception. Moving objects were followed by a trail of multiple "freeze-frame" images, which dissipated promptly when motion ceased. A 48-year-old woman receiving nefazodone (400 mg daily at bedtime) reported a similar phenomenon, with visual trails following moving objects. In both patients, vision returned to normal after the dosage of nefazodone was reduced or eliminated.CONCLUSIONS:
Nefazodone toxicity can result in akinetopsia, characterized by the inability to perceive motion in a normal, smooth fashion; persistence of multiple, strobelike images; and visual trails behind moving objects. In this rare syndrome, stationary elements are perceived normally, indicating that nefazodone causes selective impairment of pathways involved in motion processing in the visual system.
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Base de dados:
MEDLINE
Assunto principal:
Transtornos da Percepção
/
Antagonistas da Serotonina
/
Triazóis
/
Inibidores Seletivos de Recaptação de Serotonina
/
Antidepressivos de Segunda Geração
/
Percepção de Movimento
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am J Ophthalmol
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos