Cell composition and immunohistochemical detection of VEGF, TGF-beta, and TNF-alpha in proliferative vitreoretinopathy.
J Submicrosc Cytol Pathol
; 31(3): 363-6, 1999 Jul.
Article
em En
| MEDLINE
| ID: mdl-10626004
ABSTRACT
Formation of vascularized membranes inside the vitreous leads to retinal detachment and blindness. In this paper it is shown that vitreal membranes are composed of newly formed vessels and myofibroblasts, immersed in a loose stroma with sparse histocytes. Vascular endothelial growth factor (VEGF) is clearly present in cellular constituents of the membranes and, therefore, represents a fundamental cytokine in their formation, while transforming growth factor-beta (TGF-beta) and tumor necrosis factor-alpha (TNF-alpha) are not. Considering that the composition of vitreal membranes clearly resembles scar tissue, the absence of TGF-beta in the membranes could explain their peculiar histological appearance.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Crescimento Endotelial
/
Fator de Crescimento Transformador beta
/
Linfocinas
/
Fator de Necrose Tumoral alfa
/
Vitreorretinopatia Proliferativa
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Submicrosc Cytol Pathol
Assunto da revista:
PATOLOGIA
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Itália