Characterization, regulation of the expression and putative roles of two glutathione peroxidase proteins found in the mouse epididymis.
J Reprod Fertil Suppl
; 53: 157-62, 1998.
Article
em En
| MEDLINE
| ID: mdl-10645275
ABSTRACT
Two glutathione peroxidase genes (gpx5 and gpx3) were found to be expressed in the mouse epididymis. Gpx5 was shown to be epididymis specific and restricted to the caput epididymidis, while gpx3 was found to be expressed in a wide array of tissues including the caput, corpus and cauda epididymides. Both single copy genes are regulated by androgens as well as being developmentally regulated during postnatal ontogenesis of the epididymis. In this report data collected to date concerning the mechanisms by which these genes are regulated in the mouse epididymis are summarized. The putative roles of these antioxidant enzymes in the sperm maturation process are discussed.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Maturação do Esperma
/
Hormônios Testiculares
/
RNA Mensageiro
/
Regulação da Expressão Gênica
/
Epididimo
/
Glutationa Peroxidase
Limite:
Animals
Idioma:
En
Revista:
J Reprod Fertil Suppl
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
França